Novel aspects of the molecular mechanisms controlling insulin secretion.
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CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cellsOverexpression of alpha2A-adrenergic receptors contributes to type 2 diabetesVoltage-gated calcium channelsPreferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent isletsSubplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretionThe secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- miceControl of the intracellular redox state by glucose participates in the insulin secretion mechanismLessons from models of pancreatic beta cells for engineering glucose-sensing cellsBeta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationCell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeletonCellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.Dynamics of insulin secretion and the clinical implications for obesity and diabetesAnalysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysisImaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell lineStatistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cellsCorelease of dopamine and GABA by a retinal dopaminergic neuronA computational systems analysis of factors regulating α cell glucagon secretion.Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24.Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells.Newcomer insulin secretory granules as a highly calcium-sensitive poolExploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker.The granular chloride channel ClC-3 is permissive for insulin secretion.The role of the transcription factor ETV5 in insulin exocytosis.Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.L-type calcium channels and psychiatric disorders: A brief review.Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells.Regulation of calcium in pancreatic α- and β-cells in health and disease.Reactive aldehydes--second messengers of free radicals in diabetes mellitus.Role of non-coding RNAs in pancreatic beta-cell development and physiology.
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Novel aspects of the molecular mechanisms controlling insulin secretion.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 29 May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Novel aspects of the molecular mechanisms controlling insulin secretion.
@en
Novel aspects of the molecular mechanisms controlling insulin secretion.
@nl
type
label
Novel aspects of the molecular mechanisms controlling insulin secretion.
@en
Novel aspects of the molecular mechanisms controlling insulin secretion.
@nl
prefLabel
Novel aspects of the molecular mechanisms controlling insulin secretion.
@en
Novel aspects of the molecular mechanisms controlling insulin secretion.
@nl
P2093
P2860
P1476
Novel aspects of the molecular mechanisms controlling insulin secretion.
@en
P2093
Fernando Abdulkader
Juris Galvanovskis
Matthias Braun
Michael B Hoppa
P2860
P304
P356
10.1113/JPHYSIOL.2008.155317
P407
P577
2008-05-29T00:00:00Z