Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
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Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsThe Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca.Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat modelParthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardiumKEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cellsTargeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player.Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.Perspectives on natural product epigenetic modulators in chemical biology and medicine.Sesquiterpene lactones: adverse health effects and toxicity mechanisms.Parthenolide Induces Apoptosis in Committed Progenitor AML Cell line U937 via Reduction in Osteopontin.The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells.Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.Inhibitory effects of parthenolide on the activity of NF-κB in multiple myeloma via targeting TRAF6.Targeting acute myeloid leukemia stem cell signaling by natural products.Reversing resistance of multidrug-resistant hepatic carcinoma cells with parthenolide.Anticancer Natural Compounds as Epigenetic Modulators of Gene ExpressionComparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosisNon-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6J mice.Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia
P2860
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P2860
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@en
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@nl
type
label
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@en
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@nl
prefLabel
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@en
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
@nl
P1476
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells
@en
P2093
Arkadiusz Orzechowski
Barbara Gajkowska
P304
P356
10.2478/V10042-008-0019-2
P50
P577
2008-01-01T00:00:00Z