Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
about
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline.Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery.A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection.Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis.Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosisAllosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.Antibiotic efficacy-context matters.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis.2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Impact of Clofazimine Dosing on Treatment-Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis.The F1Fo-ATP Synthase β Subunit Is Required for Candida albicans Pathogenicity Due to Its Role in Carbon Flexibility.Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosisChallenging the Drug-Likeness Dogma for New Drug Discovery in TuberculosisChallenges and recent progress in drug discovery for tropical diseases
P2860
Q33913678-18BEC010-44F8-4F09-946B-1335722386CCQ38995175-5D2A4B81-0945-4724-924C-014C5D3816FDQ39235946-8DE7EC98-8DB5-45DE-A781-5DC1C0CF0678Q40063754-16171523-3C02-4B00-9948-7737926DBC32Q40112549-201E804A-FC40-4652-9CE9-681455288E9DQ40197457-F0771B86-2012-46F4-8CDB-8694479B5E73Q40257197-268FDE4C-4DBC-4E25-B5AF-4CAB8E4949A5Q42263053-426C88FA-B1EA-4E75-8CED-5FD4197F1F3BQ47093618-0BB39285-61D1-436F-96DA-5DA2EF5CC726Q47133089-093ADDC6-74B3-4D4A-AAE5-E81C408ED06BQ47138047-DD77A974-F996-4AF5-A61A-AE9A629CF13FQ47429185-AC84FE36-07F8-4D3C-8027-55B3676861EFQ47446710-08A57A3B-9EA3-4B33-B15F-A8821EC58D43Q48505400-C549AD6A-A04F-459A-90C9-06C91CDA1757Q50077291-8F461A0C-3FC5-43D4-A29D-B1E93F29F310Q52664543-3017B4D4-C09C-4055-9D42-38E37C987948Q52688603-37475186-24D5-47DC-AC7E-B642FAA8C6B9Q53686602-7CE95ACB-6A09-4178-B4BD-261E44045A01Q55399399-E22CDBE0-4A6D-4916-9298-8F99154ACD6AQ57291166-12F3A1D5-53D5-4E61-A43B-8E134EFFAF00Q57656314-DEEE69E9-406C-443D-ABA1-98002B35AD38Q59073293-EA5BAD9E-FE08-4E5B-9B78-3BC753DDF4ED
P2860
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 August 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@en
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@nl
type
label
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@en
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@nl
prefLabel
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@en
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@nl
P2093
P2860
P50
P356
P1476
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.
@en
P2093
John H Adamson
Peter M Finin
Shannon L Russell
Surendranadha R Jonnala
P2860
P2888
P356
10.1038/NCOMMS12393
P407
P577
2016-08-10T00:00:00Z
P6179
1016066971