G protein betagamma subunits as targets for small molecule therapeutic development.
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Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targetingActivators of G protein signaling in the kidneyInhibition of dopamine transporter activity by G protein βγ subunitsInhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cellsKrüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.Canonical and noncanonical g-protein signaling helps coordinate actin dynamics to promote macrophage phagocytosis of zymosanEvaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunitsRational design of a selective covalent modifier of G protein βγ subunits.Direct-reversible binding of small molecules to G protein βγ subunits.Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.Parasite neuropeptide biology: Seeding rational drug target selection?Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunitsNovel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.Inhibiting G protein βγ signaling blocks prostate cancer progression and enhances the efficacy of paclitaxel.The Gαi-GIV binding interface is a druggable protein-protein interactionKinetics of the early events of GPCR signalling.The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand.Molecular Approaches To Target GPCRs in Cancer Therapy.
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P2860
G protein betagamma subunits as targets for small molecule therapeutic development.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
G protein betagamma subunits as targets for small molecule therapeutic development.
@en
G protein betagamma subunits as targets for small molecule therapeutic development.
@nl
type
label
G protein betagamma subunits as targets for small molecule therapeutic development.
@en
G protein betagamma subunits as targets for small molecule therapeutic development.
@nl
prefLabel
G protein betagamma subunits as targets for small molecule therapeutic development.
@en
G protein betagamma subunits as targets for small molecule therapeutic development.
@nl
P2093
P2860
P1476
G protein betagamma subunits as targets for small molecule therapeutic development.
@en
P2093
Alan V Smrcka
Axel L Dessal
David M Lehmann
P2860
P304
P356
10.2174/138620708784534761
P577
2008-06-01T00:00:00Z