Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis
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Dysregulation of glutathione homeostasis in neurodegenerative diseasesDisrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80RPurification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoanLeishmania tarentolaeSuperoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance.Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytesBiological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol ModificationsParsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Post-translational modification of Cu/Zn superoxide dismutase under anaerobic conditions.Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase.Temporal dynamics of glyoxalase 1 in secondary neuronal injuryOligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols.S-glutathionylation: from molecular mechanisms to health outcomesDisulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma.Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutantsRegulation of CuZnSOD and its redox signaling potential: implications for amyotrophic lateral sclerosisStrategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methodsN-terminal strands of filamin Ig domains act as a conformational switch under biological forces.Study of the effect of varicocelectomy on sperm proteins expression in patients with varicocele and poor sperm quality by using two-dimensional gel electrophoresisDownregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells.Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants.Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive.Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Protein S-glutathiolation: redox-sensitive regulation of protein function.Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers.Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.Modulation of SOD1 Subcellular Localization by Transfection with Wild- or Mutant-type SOD1 in Primary Neuron and Astrocyte Cultures from ALS Mice.Computing energy landscape maps and structural excursions of proteinsIn vivo tagging and characterization of S-glutathionylated proteins by a chemoenzymatic method.Nodularin exposure induces SOD1 phosphorylation and disrupts SOD1 co-localization with actin filamentsRedox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.Is SOD1 loss of function involved in amyotrophic lateral sclerosis?Proteome-wide detection and quantitative analysis of irreversible cysteine oxidation using long column UPLC-pSRM.Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damageMnSOD in oxidative stress response-potential regulation via mitochondrial protein influx.Computational approaches to understanding protein aggregation in neurodegeneration.Non-native soluble oligomers of Cu/Zn superoxide dismutase (SOD1) contain a conformational epitope linked to cytotoxicity in amyotrophic lateral sclerosis (ALS).
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Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 19 March 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Modifications of superoxide di ...... amyotrophic lateral sclerosis
@en
Modifications of superoxide dismutase
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type
label
Modifications of superoxide di ...... amyotrophic lateral sclerosis
@en
Modifications of superoxide dismutase
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prefLabel
Modifications of superoxide di ...... amyotrophic lateral sclerosis
@en
Modifications of superoxide dismutase
@nl
P2093
P2860
P356
P1476
Modifications of superoxide di ...... amyotrophic lateral sclerosis
@en
P2093
Joshua K Jordon
Kyle C Wilcox
Michael Caplow
Rachel L Redler
P2860
P304
13940-13947
P356
10.1074/JBC.M809687200
P407
P577
2009-03-19T00:00:00Z