Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism
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A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription ElongationBridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residueMillisecond dynamics of RNA polymerase II translocation at atomic resolutionTrigger loop folding determines transcription rate of Escherichia coli's RNA polymeraseWide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo.Unveiling translocation intermediates of RNA polymeraseColiphage HK022 Nun protein inhibits RNA polymerase translocationThe elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome.RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movementInteractions between RNA polymerase and the "core recognition element" counteract pausingTrigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis.High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop.Mechanisms of backtrack recovery by RNA polymerases I and II.TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycleFunctional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitutionA Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.Nucleosomal arrangement affects single-molecule transcription dynamics.Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network ModelsTranscription factors IIS and IIF enhance transcription efficiency by differentially modifying RNA polymerase pausing dynamics.Molecular mechanisms of transcription through single-molecule experiments.Regulation of Transcript Elongation.Colloidal heat engines: a review.Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity.Conformational selection and induced fit as a useful framework for molecular motor mechanisms.Energy-based scheme for reconstruction of piecewise constant signals observed in the movement of molecular machines.Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.On the move.The mechano-chemistry of a monomeric reverse transcriptase.Iterated function systems for DNA replication.Hinge action versus grip in translocation by RNA polymerase.Dynamics of a mechanical system with multiple degrees of freedom out of thermal equilibrium.Dynamics of bridge helix bending in RNA polymerase II.Template-Directed Copolymerization, Random Walks along Disordered Tracks, and Fractals.Stochastic resetting in backtrack recovery by RNA polymerases.RNA-DNA and DNA-DNA base-pairing at the upstream edge of the transcription bubble regulate translocation of RNA polymerase and transcription rate.Active site closure stabilizes the backtracked state of RNA polymerase
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Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Complete dissection of transcr ...... in a linear ratchet mechanism
@en
Complete dissection of transcr ...... in a linear ratchet mechanism.
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type
label
Complete dissection of transcr ...... in a linear ratchet mechanism
@en
Complete dissection of transcr ...... in a linear ratchet mechanism.
@nl
prefLabel
Complete dissection of transcr ...... in a linear ratchet mechanism
@en
Complete dissection of transcr ...... in a linear ratchet mechanism.
@nl
P2093
P2860
P50
P356
P1433
P1476
Complete dissection of transcr ...... in a linear ratchet mechanism
@en
P2093
Lucyna Lubkowska
Manchuta Dangkulwanich
Mikhail Kashlev
Shixin Liu
P2860
P304
P356
10.7554/ELIFE.00971
P407
P577
2013-09-24T00:00:00Z