The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
about
Drugs under preclinical and clinical study for treatment of acute and chronic lymphoblastic leukemiaDiscovery of new anticancer agents from higher plantsTargeting translation initiation in breast cancerDiscovery of Anticancer Agents of Diverse Natural OriginTherapeutic potential of the translation inhibitor silvestrol in hepatocellular cancerThe novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivoHyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata.The continuing search for antitumor agents from higher plantsThe CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia modelRocaglamide, silvestrol and structurally related bioactive compounds from Aglaia speciesPotential of plant-derived natural products in the treatment of leukemia and lymphoma17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cellsEukaryotic initiation factor 4F: a vulnerability of tumor cells.RNA helicases in infection and disease.Inhibition of translation by cytotrienin A--a member of the ansamycin familyTranscriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation.Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemiaInhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.Photodynamic activity of plant extracts from Sarawak, Borneo.Targeting the eIF4F translation initiation complex: a critical nexus for cancer developmentA phenolic ester from Aglaia loheri leaves reveals cytotoxicity towards sensitive and multidrug-resistant cancer cells.eIF4A1 is a promising new therapeutic target in ER-negative breast cancer.The relevance of higher plants in lead compound discovery programs.Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry.Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative diseaseEmerging therapeutics targeting mRNA translationSilvestrol induces early autophagy and apoptosis in human melanoma cellsTargeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesisCyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa.Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributorTranslation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status.Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis.
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P2860
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The novel plant-derived agent ...... leukemia in vitro and in vivo
@en
The novel plant-derived agent ...... leukemia in vitro and in vivo.
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type
label
The novel plant-derived agent ...... leukemia in vitro and in vivo
@en
The novel plant-derived agent ...... leukemia in vitro and in vivo.
@nl
prefLabel
The novel plant-derived agent ...... leukemia in vitro and in vivo
@en
The novel plant-derived agent ...... leukemia in vitro and in vivo.
@nl
P2093
P2860
P1433
P1476
The novel plant-derived agent ...... leukemia in vitro and in vivo
@en
P2093
A Douglas Kinghorn
Amy J Johnson
Amy Lehman
Bao-Ning Su
Darlene M Rozewski
David J Newman
David Jarjoura
David M Lucas
Derek A West
Gerard Lozanski
P2860
P304
P356
10.1182/BLOOD-2008-09-175430
P407
P577
2009-02-03T00:00:00Z