Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study. - Wikidata - wikimedia - TriplyDB

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

http://www.wikidata.org/entity/Q37193773

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Molecular mechanism of action of metformin: old or new insights?How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Pharmacogenetic studies update in type 2 diabetes mellitus Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents Cellular and molecular mechanisms of metformin: an overview Metformin and the gastrointestinal tract Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery Personalized medicine in Type 2 Diabetes Current understanding of the pharmacogenomics of metformin.Membrane transporters in drug development Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs.The role of variants regulating metformin transport and action in women with polycystic ovary syndrome.A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing The role of genetic factors and kidney and liver function in glycemic control in type 2 diabetes patients on long-term metformin and sulphonylurea cotreatment.An update on the pharmacogenomics of metformin: progress, problems and potential.Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program Personalized medicine in diabetes mellitus: current opportunities and future prospects Pharmacogenetics in type 2 diabetes: potential implications for clinical practice Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish.Metformin pathways: pharmacokinetics and pharmacodynamics Impact of ATM and SLC22A1 Polymorphisms on Therapeutic Response to Metformin in Iranian Diabetic Patients.Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.Pharmacogenetics of oral antidiabetic drugs.Pharmacogenetics and personalized treatment of type 2 diabetes The pharmacogenetics of type 2 diabetes: a systematic review.Genetic susceptibility to type 2 diabetes and implications for therapy.Disposition of metformin: variability due to polymorphisms of organic cation transporters.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.The role of pharmacogenetics in drug disposition and response of oral glucose-lowering drugs.Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here?Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.Antidiabetic agents and endothelial dysfunction - beyond glucose control.Genetics of drug response in type 2 diabetes.Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions.Using Personalized Medicine in the Management of Diabetes Mellitus.

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Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

http://www.wikidata.org/entity/Q37193773

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bilimsel makale

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scientific article published on 31 March 2009

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vedecký článok

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vědecký článek

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name

Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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type

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Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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prefLabel

Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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Reduced-function SLC22A1 polym ...... to metformin: a GoDARTS study.

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Alex S F Doney

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Andrew D Morris

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Charlotte H Kimber

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Colin N A Palmer

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Graham Leese

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Kaixin Zhou

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Louise A Donnelly

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Peter T Donnan

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P2860

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

PLINK: a tool set for whole-genome association and population-based linkage analyses

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

Importance of the intestine as a site of metformin-stimulated glucose utilization

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

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