The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. - Wikidata - wikimedia - TriplyDB

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

http://www.wikidata.org/entity/Q37194765

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Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression Interaction of organic cation transporter 3 (SLC22A3) and amphetamine Solvents and Parkinson disease: a systematic review of toxicological and epidemiological evidence Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research Toxin-Induced Experimental Models of Learning and Memory Impairment What Mechanisms Are Responsible for the Reuptake of Levodopa-Derived Dopamine in Parkinsonian Striatum?Microstructural changes in the substantia nigra of asymptomatic agricultural workers Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies.Neurosteroid transport by the organic solute transporter OSTα-OSTβ.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Exercise protects against MPTP-induced neurotoxicity in mice.Uptake of pramipexole by human organic cation transporters.Astrocytes and therapeutics for Parkinson's disease.Taste of a pill: organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands.Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3 Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo Dopamine transporter loss in 6-OHDA Parkinson's model is unmet by parallel reduction in dopamine uptake.Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia.Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice.The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes Changes in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure.Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice.A guide to neurotoxic animal models of Parkinson's disease Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3.Industrial toxicants and Parkinson's disease.Classic and new animal models of Parkinson's disease.Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain.Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3 Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.Effects of L-arginine pre-treatment in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's diseases in Balb/c mice Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3 Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.Catecholamine/Serotonin interactions: systems thinking for brain function and disease Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation.Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.The role of glia in stress: polyamines and brain disorders

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The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

http://www.wikidata.org/entity/Q37194765

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The organic cation transporter ...... striatal dopaminergic pathway.

@en

The organic cation transporter ...... striatal dopaminergic pathway.

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type

label

The organic cation transporter ...... striatal dopaminergic pathway.

@en

The organic cation transporter ...... striatal dopaminergic pathway.

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prefLabel

The organic cation transporter ...... striatal dopaminergic pathway.

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The organic cation transporter ...... striatal dopaminergic pathway.

@nl

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PNAS.0900358106

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Proceedings of the National Academy of Sciences of the United States of America

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The organic cation transporter ...... striatal dopaminergic pathway.

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Jonathan A Javitch

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Joseph Panza

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Kim Tieu

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Mamata Hatwar

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Mei Cui

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Nazzareno Ballatori

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Phillip M Rappold

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Radha Aras

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Whitney V Christian

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P2860

The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation

Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice

Parkinson's disease: mechanisms and models

Methamphetamine-induced striatal dopamine release, behavior changes and neurotoxicity in BALB/c mice.

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8043-8048

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scholarly article

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10.1073/PNAS.0900358106

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19

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106

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Serge Przedborski

Vernice Jackson-Lewis

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2009-04-29T00:00:00Z

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24403124

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19416912

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2683105

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