A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
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Therapeutic Oligonucleotides Targeting Liver Disease: TTR AmyloidosissiRNA Versus miRNA as Therapeutics for Gene SilencingsiRNA delivery to the lung: what's new?miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agentsAn Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNAG-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex foldNanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides.Silencing disease genes in the laboratory and the clinicSequence-non-specific effects of RNA interference triggers and microRNA regulators.Infrared multiphoton dissociation of small-interfering RNA anions and cationsOligonucleotide-based strategies to combat polyglutamine diseases.Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles.2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.Improved siRNA/shRNA functionality by mismatched duplex.Lipid and polymeric carrier-mediated nucleic acid delivery.An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseasesThermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAsInhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy.Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexessiRNAmod: A database of experimentally validated chemically modified siRNAsImproved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.RNAi screening: tips and techniques.8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.Improving gene silencing of siRNAs via tricyclo-DNA modificationInhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.Identification of siRNA delivery enhancers by a chemical library screen.Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery.Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression.In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are importantGene silencing activity of siRNA molecules containing phosphorodithioate substitutionsDevelopment of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.The highly conserved 5' untranslated region as an effective target towards the inhibition of Enterovirus 71 replication by unmodified and appropriate 2'-modified siRNAs.Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In VivoMonitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods.Current development of targeted oligonucleotide-based cancer therapies: Perspective on HER2-positive breast cancer treatment.Design of siRNA Therapeutics from the Molecular Scale
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P2860
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 March 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A large-scale chemical modific ...... igh stability and low toxicity
@en
A large-scale chemical modific ...... gh stability and low toxicity.
@nl
type
label
A large-scale chemical modific ...... igh stability and low toxicity
@en
A large-scale chemical modific ...... gh stability and low toxicity.
@nl
prefLabel
A large-scale chemical modific ...... igh stability and low toxicity
@en
A large-scale chemical modific ...... gh stability and low toxicity.
@nl
P2093
P2860
P50
P356
P1476
A large-scale chemical modific ...... igh stability and low toxicity
@en
P2093
Anne F Nielsen
B Ravindra Babu
Chuanzheng Zhou
Cordula Andree
Dalibor Odadzic
Dmytro Honcharenko
Elke Müller
Eugenio Fava
Georgii V Bobkov
P2860
P304
P356
10.1093/NAR/GKP106
P407
P50
P577
2009-03-12T00:00:00Z