Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias.
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Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanismTargeting cell cycle regulators in hematologic malignancies.Repurposing Kinase Inhibitors as Antiviral Agents to Control Influenza A Virus Replication.Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer.Vincristine activates c-Jun N-terminal kinase in chronic lymphocytic leukaemia in vivoA cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer.Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancerCell cycle proteins as promising targets in cancer therapyDinaciclib for the treatment of breast cancer.Highlights of the Latest Advances in Research on CDK Inhibitors.Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: a systematic review.Overview of CDK9 as a target in cancer research.Emerging cell cycle inhibitors for acute myeloid leukemia.Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice.Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl-xL silenced cells.Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression.CDK9 inhibitors in acute myeloid leukemia.Managing Tumor Lysis Syndrome in the Era of Novel Cancer TherapiesTargeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
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Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Clinical and laboratory studie ...... CH 727965) in acute leukemias.
@en
Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib
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type
label
Clinical and laboratory studie ...... CH 727965) in acute leukemias.
@en
Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib
@nl
prefLabel
Clinical and laboratory studie ...... CH 727965) in acute leukemias.
@en
Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib
@nl
P2093
P2860
P1476
Clinical and laboratory studie ...... CH 727965) in acute leukemias.
@en
P2093
Alison Walker
Edward A Sausville
Eric J Feldman
Ivana Gojo
Jennifer Poon
Karen Small
Maria R Baer
Mariola Sadowska
Rajat Bannerji
P2860
P2888
P304
P356
10.1007/S00280-013-2249-Z
P577
2013-08-15T00:00:00Z