Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner. - Wikidata - wikimedia - TriplyDB

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.

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New Insights into Wnt-Lrp5/6-β-Catenin Signaling in Mechanotransduction Regulation of Wnt/β-catenin signaling within and from osteocytes Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading Mechanotransduction in musculoskeletal tissue regeneration: effects of fluid flow, loading, and cellular-molecular pathways.An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations Rest intervals reduce the number of loading bouts required to enhance bone formation.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway LRP receptor family member associated bone disease Cortical and trabecular bone adaptation to incremental load magnitudes using the mouse tibial axial compression loading model.Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation Mechanosignaling in bone health, trauma and inflammation.Genetic Approaches To Identifying Novel Osteoporosis Drug Targets.Exploiting the WNT Signaling Pathway for Clinical Purposes.Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease.The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5.Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone.The modulation of stem cell behaviors by functionalized nanoceramic coatings on Ti-based implants.

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Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.

http://www.wikidata.org/entity/Q37200255

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 28 June 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Mechanotransduction in bone ti ...... in a surface-selective manner.

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Mechanotransduction in bone ti ...... in a surface-selective manner.

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Mechanotransduction in bone ti ...... in a surface-selective manner.

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Mechanotransduction in bone ti ...... in a surface-selective manner.

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J.BONE.2012.05.023

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Alexander G Robling

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Matthew L Warman

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Paul J Niziolek

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P2860

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Lrp5 functions in bone to regulate bone mass

Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)

High bone mass in mice expressing a mutant LRP5 gene

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

High bone density due to a mutation in LDL-receptor-related protein 5

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

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459-465

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scholarly article

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10.1016/J.BONE.2012.05.023

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3

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51

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2012-06-28T00:00:00Z

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Mechanotransduction

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3784262

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