Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.
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Getting Ready for the Dance: FANCJ Irons Out DNA WrinklesG-quadruplexes and helicasesReplication of Structured DNA and its implication in epigenetic stabilityMolecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndromeTim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathwaySingle-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicasesNovel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNARepair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase.Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATPMolecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemiaDNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.Impact of age-associated cyclopurine lesions on DNA repair helicases.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresA distinct triplex DNA unwinding activity of ChlR1 helicaseA parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands.FANCJ at the FORK.G-quadruplex recognition and remodeling by the FANCJ helicaseHelicases, G4-DNAs, and drug design.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome.Chemical modifications of DNA for study of helicase mechanismsFANCJ promotes DNA synthesis through G-quadruplex structures.Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition.The helicase DinG responds to stress due to DNA double strand breaks.Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.Escherichia coli DNA polymerase I can disrupt G-quadruplex structures during DNA replication.A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repairDetection of G-quadruplex DNA in mammalian cells
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Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.
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article científic
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bilimsel makale
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scientific article published on 09 August 2013
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vetenskaplig artikel
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Specialization among iron-sulf ...... at threaten genomic stability.
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Specialization among iron-sulf ...... at threaten genomic stability.
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Specialization among iron-sulf ...... at threaten genomic stability.
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Specialization among iron-sulf ...... at threaten genomic stability.
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Specialization among iron-sulf ...... at threaten genomic stability.
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Specialization among iron-sulf ...... at threaten genomic stability.
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P2093
P2860
P50
P356
P1476
Specialization among iron-sulf ...... at threaten genomic stability.
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P2093
Florian Hamon
Fourbears George
Jochen Kuper
Joshua A Sommers
Robert M Brosh
Sanjay Kumar Bharti
P2860
P304
28217-28229
P356
10.1074/JBC.M113.496463
P407
P577
2013-08-09T00:00:00Z