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Chromosomal instability determines taxane response

Chromosomal instability determines taxane response

http://www.wikidata.org/entity/Q37208871

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Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Tumour heterogeneity and the evolution of polyclonal drug resistance Quantitative assessment of chromosome instability induced through chemical disruption of mitotic progression Microtubule-binding agents: a dynamic field of cancer therapeutics.A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect Predicting response to preoperative chemotherapy agents by identifying drug action on modeled microRNA regulation networks Tracking genomic cancer evolution for precision medicine: the lung TRACERx study Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.Early Detection of Treatment-Induced Mitotic Arrest Using Temporal Diffusion Magnetic Resonance Spectroscopy.The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples.MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.p53 suppresses structural chromosome instability after mitotic arrest in human cells.Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.Chromosomal instability confers intrinsic multidrug resistance.New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Usp7 protects genomic stability by regulating Bub3.Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.The origins of cancer robustness and evolvability.DNA repair and personalized breast cancer therapy Cancer chromosomal instability: therapeutic and diagnostic challenges.Cancer heterogeneity: implications for targeted therapeutics.Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome Taxane pathway.The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells A novel measure of chromosome instability can account for prognostic difference in multiple myeloma.Genomic instability and copy-number heterogeneity of chromosome 19q, including the kallikrein locus, in ovarian carcinomas.NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma Novel actions of next-generation taxanes benefit advanced stages of prostate cancer.High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications Targeting karyotypic complexity and chromosomal instability of cancer cells.Losing balance: the origin and impact of aneuploidy in cancer Chromosome instability and benefit from adjuvant anthracyclines in breast cancer.

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Chromosomal instability determines taxane response

http://www.wikidata.org/entity/Q37208871

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 19 May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Chromosomal instability determines taxane response

@en

Chromosomal instability determines taxane response.

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type

label

Chromosomal instability determines taxane response

@en

Chromosomal instability determines taxane response.

@nl

prefLabel

Chromosomal instability determines taxane response

@en

Chromosomal instability determines taxane response.

@nl

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PNAS.0811835106

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Proceedings of the National Academy of Sciences of the United States of America

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Chromosomal instability determines taxane response

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P2093

Barbara Nicke

http://www.w3.org/2001/XMLSchema#string

David Endesfelder

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Gert Auer

http://www.w3.org/2001/XMLSchema#string

Jens K Habermann

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Jie-Guang Chen

http://www.w3.org/2001/XMLSchema#string

Maik Kschischo

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Marion Schuett

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Paul Wylie

http://www.w3.org/2001/XMLSchema#string

Qiyuan Li

http://www.w3.org/2001/XMLSchema#string

Rajat Roy

http://www.w3.org/2001/XMLSchema#string

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Functional discovery via a compendium of expression profiles.

Aneuploid colon cancer cells have a robust spindle checkpoint

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

Identification of genes periodically expressed in the human cell cycle and their expression in tumors

Human cancer cells commonly acquire DNA damage during mitotic arrest.

Karyotypic "state" as a potential determinant for anticancer drug discovery

Origin of multidrug resistance in cells with and without multidrug resistance genes: chromosome reassortments catalyzed by aneuploidy.

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.

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8671-8676

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scholarly article

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10.1073/PNAS.0811835106

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21

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106

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Aron Charles Eklund

Zoltan Szallasi

Charles Swanton

James D Brenton

Thomas J Hardcastle

Charlotte K Y Ng

Julian Downward

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2009-05-19T00:00:00Z

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24442266

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19458043

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2688979

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