Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
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Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1Structural requirements and dynamics of mitosin-kinetochore interaction in M phaseHuman BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCThe Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregationImpairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomasPhosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignmentCrystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointDishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1.Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionSimian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinaseBub1 regulates chromosome segregation in a kinetochore-independent mannerIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignmentZW10 helps recruit dynactin and dynein to the kinetochoreMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochoresCENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells.Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiaeCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexRNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulationMicrotubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresGene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayBub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesisThe checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiationA new look at kinetochore structure in vertebrate somatic cells using high-pressure freezing and freeze substitutionMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsMAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activityQuantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fateThe crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochoresCheckpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingSpindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activityBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisMad2 transiently associates with an APC/p55Cdc complex during mitosisSpindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochoresHuman MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
P2860
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P2860
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
description
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im Mai 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 30 May 1997)
@en
wetenschappelijk artikel (gepubliceerd op 1997/05/30)
@nl
наукова стаття, опублікована в травні 1997
@uk
مقالة علمية (نشرت في 30-5-1997)
@ar
name
Kinetochore localization of mu ...... int response to spindle damage
@ast
Kinetochore localization of mu ...... int response to spindle damage
@en
type
label
Kinetochore localization of mu ...... int response to spindle damage
@ast
Kinetochore localization of mu ...... int response to spindle damage
@en
prefLabel
Kinetochore localization of mu ...... int response to spindle damage
@ast
Kinetochore localization of mu ...... int response to spindle damage
@en
P1433
P1476
Kinetochore localization of mu ...... int response to spindle damage
@en
P2093
P304
P356
10.1016/S0092-8674(00)80255-X
P407
P577
1997-05-01T00:00:00Z