The flavivirus polymerase as a target for drug discovery.
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Molecular targets for flavivirus drug discoveryOpen drug discovery for the Zika virusStructure and functionality in flavivirus NS-proteins: perspectives for drug designInhibition of protein kinase C promotes dengue virus replicationPredicting Zika virus structural biology: Challenges and opportunities for interventionPotent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingFlaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral interventionUsing the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsFocus on flaviviruses: current and future drug targetsA Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation ActivitiesLooking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approachDengue Virus Control of Type I IFN Responses: A History of Manipulation and ControlTowards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteinsPurification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitorsAnalysis of Ribonucleotide 5’ -Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-dependent RNA Polymerase Using Non-Radioactive Polymerase AssaysInhibitors compounds of the flavivirus replication processBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondDengue Virus Non-Structural Protein 5High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitorsMolecular basis for nucleotide conservation at the ends of the dengue virus genome.Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5.Functional analysis of two cavities in flavivirus NS5 polymeraseIdentifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue VirusPoint mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivoIdentification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA PolymeraseQuercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation, and binding free energy calculation.Biological and phylogenetic characteristics of yellow fever virus lineages from West Africa.West Nile virus: A re-emerging pathogen revisited.Serotype-specific differences in dengue virus non-structural protein 5 nuclear localizationUsutu virus.West Nile virus drug discovery.Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.RNA synthetic mechanisms employed by diverse families of RNA viruses.Functional interplay among the flavivirus NS3 protease, helicase, and cofactors.Regulation of Flavivirus RNA synthesis and replicationViruses and viral proteins.Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.Inhibition of dengue virus polymerase by blocking of the RNA tunnel
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The flavivirus polymerase as a target for drug discovery.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The flavivirus polymerase as a target for drug discovery.
@en
The flavivirus polymerase as a target for drug discovery.
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type
label
The flavivirus polymerase as a target for drug discovery.
@en
The flavivirus polymerase as a target for drug discovery.
@nl
prefLabel
The flavivirus polymerase as a target for drug discovery.
@en
The flavivirus polymerase as a target for drug discovery.
@nl
P2093
P50
P1433
P1476
The flavivirus polymerase as a target for drug discovery
@en
P2093
Barbara Selisko
Hughes Tolou
Jean Claude Guillemot
Julien Lescar
Karine Alvarez
Nicolas Massé
Subash Vasudevan
Thai Leong Yap
P356
10.1016/J.ANTIVIRAL.2008.06.007
P577
2008-07-09T00:00:00Z