Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.
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Bidirectional regulation of neutrophil migration by mitogen-activated protein kinasesβ-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKRBiased and g protein-independent signaling of chemokine receptorsRegulation of G protein-coupled receptors by allosteric ligandsChemokines as effector and target molecules in vascular biologyChemokine GPCR signaling inhibits β-catenin during zebrafish axis formationTargeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.Crystallographic Structure of Truncated CCL21 and the Putative Sulfotyrosine-Binding SiteInterferon-alpha subtype 11 activates NK cells and enables control of retroviral infectionFusion of CCL21 non-migratory active breast epithelial and breast cancer cells give rise to CCL21 migratory active tumor hybrid cell linesCCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infectionPhosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.Emerging concepts and approaches for chemokine-receptor drug discovery.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubilityTeaching old receptors new tricks: biasing seven-transmembrane receptors.A Pluridimensional View of Biased Agonism.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation.Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists.GRK2 targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling.β-Arrestin-mediated receptor trafficking and signal transductionEmerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingBiased signaling at chemokine receptorsMonomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysPotent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.G protein-coupled receptor kinases: more than just kinases and not only for GPCRsIn vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity.G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro.Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses.Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptorsFulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.The evolving impact of g protein-coupled receptor kinases in cardiac health and diseasePancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling
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Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Selective engagement of G prot ...... t functions of biased ligands.
@en
Selective engagement of G protein coupled receptor kinases
@nl
type
label
Selective engagement of G prot ...... t functions of biased ligands.
@en
Selective engagement of G protein coupled receptor kinases
@nl
prefLabel
Selective engagement of G prot ...... t functions of biased ligands.
@en
Selective engagement of G protein coupled receptor kinases
@nl
P2093
P2860
P356
P1476
Selective engagement of G prot ...... t functions of biased ligands.
@en
P2093
David A Zidar
Erin J Whalen
Jonathan D Violin
Robert J Lefkowitz
P2860
P304
P356
10.1073/PNAS.0904361106
P407
P577
2009-06-02T00:00:00Z