Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment
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Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicityAntiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression.Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy.Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamicsAntiprogestins in gynecological diseases.Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo studyGrowth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.Drug Repurposing for Cancer Therapy.Synergistic lethality of mifepristone and LY294002 in ovarian cancer cellsRepopulation of ovarian cancer cells after chemotherapyMifepristone improves chemo-radiation response in glioblastoma xenografts.Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation.Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity.Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
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Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mifepristone abrogates repopul ...... courses of cisplatin treatment
@en
Mifepristone abrogates repopul ...... ourses of cisplatin treatment.
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type
label
Mifepristone abrogates repopul ...... courses of cisplatin treatment
@en
Mifepristone abrogates repopul ...... ourses of cisplatin treatment.
@nl
prefLabel
Mifepristone abrogates repopul ...... courses of cisplatin treatment
@en
Mifepristone abrogates repopul ...... ourses of cisplatin treatment.
@nl
P2860
P356
P1476
Mifepristone abrogates repopul ...... courses of cisplatin treatment
@en
P2093
Alicia A Goyeneche
Elizabeth M Freeburg
P2860
P304
P356
10.3892/IJO_00000200
P577
2009-03-01T00:00:00Z