On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.
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Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.New N-aryl-N'-(3-(substituted)phenyl)-N'-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor.Evaluation in monkey of two candidate PET radioligands, [(11) C]RX-1 and [(18) F]RX-2, for imaging brain 5-HT4 receptorsRadiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.[carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain.[¹¹C]Rhodamine-123: synthesis and biodistribution in rodents.Mapping human brain fatty acid amide hydrolase activity with PET.Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier.Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains.In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors.Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1)Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRFTactics for preclinical validation of receptor-binding radiotracers.Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors.[Carboxyl-11 C]Labelling of Four High-Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography.
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P2860
On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 December 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
On quantitative relationships ...... fraction in monkey and human.
@en
On quantitative relationships ...... fraction in monkey and human.
@nl
type
label
On quantitative relationships ...... fraction in monkey and human.
@en
On quantitative relationships ...... fraction in monkey and human.
@nl
prefLabel
On quantitative relationships ...... fraction in monkey and human.
@en
On quantitative relationships ...... fraction in monkey and human.
@nl
P2093
P2860
P356
P1476
On quantitative relationships ...... fraction in monkey and human.
@en
P2093
David A Luckenbaugh
Kacey B Anderson
Kimberly J Jenko
Robert B Innis
Sami S Zoghbi
Victor W Pike
P2860
P304
P356
10.1002/JPS.22822
P407
P577
2011-12-13T00:00:00Z