Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
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DNA polymerase family X: function, structure, and cellular rolesGut Microbiota Imbalance and Base Excision Repair Dynamics in Colon CancerBase excision repair and cancerA germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformationDNA polymerase β contains a functional nuclear localization signal at its N-terminus.Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsTranslesion DNA polymerases and cancerThe K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.R152C DNA Pol β mutation impairs base excision repair and induces cellular transformationMutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in MiceLysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress.Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicityChemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.Cellular roles of DNA polymerase beta.Genome instability caused by a germline mutation in the human DNA repair gene POLB.EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells.
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P2860
Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 31 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Human DNA polymerase beta poly ...... base excision repair capacity.
@en
Human DNA polymerase beta poly ...... base excision repair capacity.
@nl
type
label
Human DNA polymerase beta poly ...... base excision repair capacity.
@en
Human DNA polymerase beta poly ...... base excision repair capacity.
@nl
prefLabel
Human DNA polymerase beta poly ...... base excision repair capacity.
@en
Human DNA polymerase beta poly ...... base excision repair capacity.
@nl
P2093
P2860
P356
P1476
Human DNA polymerase beta poly ...... base excision repair capacity.
@en
P2093
P2860
P304
P356
10.1093/NAR/GKP201
P407
P577
2009-03-31T00:00:00Z