Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function
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Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureMolecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 E81 DefectPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesHereditary breast cancer: ever more pieces to the polygenic puzzle.Mutation analysis of the AATF gene in breast cancer families.Assessment of changes in the BRCA2 and P53 genes in breast invasive ductal carcinoma in northeast Brazil.Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer familiesMutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.Loss of BRCA1-A complex function in RAP80 null tumor cellsPARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.Structural and functional implication of RAP80 ΔGlu81 mutation.Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Deciphering the BRCA1 Tumor Suppressor Network.BRCA1 tumor suppressor network: focusing on its tail.MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.A BRCA1-interacting lncRNA regulates homologous recombination.RAP80 is critical in maintaining genomic stability and suppressing tumor development.USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancerMDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombinationRAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer.Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women.Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women.Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.The ubiquitin landscape at DNA double-strand breaks.Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand BreaksInherited mutations in breast cancer genes--risk and response.Links between genome integrity and BRCA1 tumor suppression.RAP80, ubiquitin and SUMO in the DNA damage response.ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.Structural and functional characterization of the MERIT40 to understand its role in DNA repair.Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.
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Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Familial breast cancer screeni ...... s DNA damage response function
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Familial breast cancer screeni ...... DNA damage response function.
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type
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Familial breast cancer screeni ...... s DNA damage response function
@en
Familial breast cancer screeni ...... DNA damage response function.
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prefLabel
Familial breast cancer screeni ...... s DNA damage response function
@en
Familial breast cancer screeni ...... DNA damage response function.
@nl
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Familial breast cancer screeni ...... s DNA damage response function
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D Morrissey
K A Coleman
R A Greenberg
S-M Karppinen
T E Messick
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10.1038/ONC.2009.33
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2009-03-23T00:00:00Z