The insulin paradox: aging, proteotoxicity and neurodegeneration.
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Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature deathSpatial protein quality control and the evolution of lineage-specific ageingAging as an event of proteostasis collapseProtein homeostasis and aging: taking care of proteins from the cradle to the graveLinking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)Parkinson's disease, insulin resistance and novel agents of neuroprotectionIntegrated control of protein degradation in C. elegans muscleChemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationThe regulation of the autophagic network and its implications for human diseaseIncreased learning and brain long-term potentiation in aged mice lacking DNA polymerase μTDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegansAcetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersCharacterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegansProteasomal regulation of the hypoxic response modulates aging in C. elegansReduced IGF-1 signaling delays age-associated proteotoxicity in miceNeuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathwaysO-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophyA cross-study transcriptional analysis of Parkinson's disease.The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.Cross-talk of membrane lipids and Alzheimer-related proteins.Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragmentA novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Müller glia.Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans.microRNA-128a dysregulation in transgenic Huntington's disease monkeys.The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans.A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnoverLinking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators.Integration of clearance mechanisms: the proteasome and autophagy.Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.Anti-inflammatory Lactobacillus rhamnosus CNCM I-3690 strain protects against oxidative stress and increases lifespan in Caenorhabditis elegans.SMA-MAP: a plasma protein panel for spinal muscular atrophyInsulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteinsThe novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans.Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate.Ubiquitin-proteasome pathway and cellular responses to oxidative stress.
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The insulin paradox: aging, proteotoxicity and neurodegeneration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@en
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@nl
type
label
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@en
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@nl
prefLabel
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@en
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@nl
P2860
P356
P1476
The insulin paradox: aging, proteotoxicity and neurodegeneration.
@en
P2093
Andrew Dillin
Ehud Cohen
P2860
P2888
P304
P356
10.1038/NRN2474
P407
P577
2008-09-04T00:00:00Z
P5875
P6179
1014257268