Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways
about
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesCell biology of spinocerebellar ataxiaHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesTDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegansNovel polyglutamine model uncouples proteotoxicity from agingA genetic screening strategy identifies novel regulators of the proteostasis networkThe struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseLimited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph DiseaseSerotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1Toward understanding Machado-Joseph diseaseAlzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.Toward RNAi therapy for the polyglutamine disease Machado-Joseph diseaseCaenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseasesRoyal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease.Quality control compartments coming of age.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Neuronal responses to physiological stress.Aging and the aggregating proteome.Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence.Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.FET proteins regulate lifespan and neuronal integrity.Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegansIn vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model.Alternative strategy for Alzheimer's disease: stress response triggers.Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.
P2860
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P2860
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@ast
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@en
type
label
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@ast
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@en
prefLabel
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@ast
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@en
P2093
P2860
P50
P356
P1476
Neuron-specific proteotoxicity ...... the DAF-16 and HSF-1 pathways
@en
P2093
Ana Jalles
Andreia Neves-Carvalho
Heather R Brignull
Michael Ailion
Pedro Rodrigues
Richard I Morimoto
P2860
P304
P356
10.1093/HMG/DDR203
P577
2011-05-05T00:00:00Z