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Molecular kinetics of nerve growth factor receptor trafficking and activation

Molecular kinetics of nerve growth factor receptor trafficking and activation

http://www.wikidata.org/entity/Q37218752

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Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader Regulation of trafficking of activated TrkA is critical for NGF-mediated functions Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation The 5' leader of the mRNA encoding the mouse neurotrophin receptor TrkB contains two internal ribosomal entry sites that are differentially regulated.Timing-dependent actions of NGF required for cell differentiation.Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins.A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors.IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species.Three-dimensional distribution of TrkA neurotrophin receptors in neurite varicosities of differentiated PC12 cells treated with NGF determined by immunoelectron tomography.Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms.A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi.Nerve conduits and growth factor delivery in peripheral nerve repair.Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.Biogenesis and function of the NGF/TrkA signaling endosome Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' disease.Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1.Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis.Nerve growth factor-mediated neurite outgrowth via regulation of Rab5.HAND transcription factors are required for neonatal sympathetic neuron survival.A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV)p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.Persistent TrkA activity is necessary to maintain transcription in neuronally differentiated PC12 cells.PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.Sustained MAPK activation is dependent on continual NGF receptor regeneration.Crypt cell markers in the olfactory organ of Poecilia reticulata: analysis and comparison with the fish model Danio rerio.TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.TGF-β and IL-6 family signalling crosstalk: an integrated model.

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Molecular kinetics of nerve growth factor receptor trafficking and activation

http://www.wikidata.org/entity/Q37218752

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 June 2002

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Molecular kinetics of nerve growth factor receptor trafficking and activation

@en

Molecular kinetics of nerve growth factor receptor trafficking and activation.

@nl

type

label

Molecular kinetics of nerve growth factor receptor trafficking and activation

@en

Molecular kinetics of nerve growth factor receptor trafficking and activation.

@nl

prefLabel

Molecular kinetics of nerve growth factor receptor trafficking and activation

@en

Molecular kinetics of nerve growth factor receptor trafficking and activation.

@nl

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Journal of Biological Chemistry

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Molecular kinetics of nerve growth factor receptor trafficking and activation

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P2093

Brian B Rudkin

http://www.w3.org/2001/XMLSchema#string

Jérôme Jullien

http://www.w3.org/2001/XMLSchema#string

Louis F Reichardt

http://www.w3.org/2001/XMLSchema#string

Vincent Guili

http://www.w3.org/2001/XMLSchema#string

P2860

Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

Neurotrophin signaling via Trks and p75.

Nerve growth factor nonresponsive pheochromocytoma cells: altered internalization results in signaling dysfunction

Molecular and biochemical characterization of the human trk proto-oncogene

Intracellular functions of N-linked glycans

Setting the standards: quality control in the secretory pathway

Identification of N- and O-linked oligosaccharides in human seminal vesicles.

Regulation of receptor tyrosine kinase signaling by endocytic trafficking.

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation

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38700-38708

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scholarly article

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10.1074/JBC.M202348200

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P433

41

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277

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2002-06-07T00:00:00Z

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11318972

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12055187

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2693056

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