RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.
about
Oligonucleotide Therapies: The Past and the PresentAbasic pivot substitution harnesses target specificity of RNA interferenceAllele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patientsExploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAsOligonucleotide-based strategies to combat polyglutamine diseases.Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells.Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells.Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.Practical and Reliable Synthesis of 1,2-Dideoxy-d-ribofuranose and its Application in RNAi Studies.Exploring PAZ/3'-overhang interaction to improve siRNA specificity. A combined experimental and modeling study.
P2860
Q27002403-53922CE7-3605-4CA1-8ABC-FA0932403BC2Q27339381-1630CC53-DBF7-4567-856F-4C26077C4FD7Q28542911-ADF12126-8601-4202-AA4E-416D753A8EE6Q33632395-286D2572-1346-4264-B5CA-95DB235768DBQ33791247-6EF722A6-8788-45B3-8B4E-B501E8B37491Q33939348-D72C541C-5816-4237-8BD9-149181F7793FQ37483574-A40B403C-5538-4280-AB4C-D27ED8554E00Q37539531-799F3D3F-050F-41EB-B886-6849551412D8Q37671130-5957396A-E56D-4C55-945A-F88E423383D7Q37723428-3101858A-9A86-4BDF-A98C-43B9E3634C8BQ38167681-8F024DB5-E548-4BED-8261-88014DF68E81Q40609867-4E0E2A14-292F-4072-82D5-4B41ACAC4D82Q51542935-529DDAB1-B310-4157-8DA7-17173152E16CQ55302171-10F199F9-E15F-42BC-9B63-7DA39C2EAEB4
P2860
RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 July 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@en
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@nl
type
label
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@en
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@nl
prefLabel
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@en
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@nl
P2093
P2860
P356
P1476
RNA duplexes with abasic subst ...... ngtin and ataxin-3 expression.
@en
P2093
David R Corey
Hannah Pendergraff
Jeremy G Lackey
K Jayaprakash Narayanannair
Kallanthottathil G Rajeev
Muthiah Manoharan
Satya Kuchimanchi
P2860
P304
P356
10.1093/NAR/GKT594
P407
P577
2013-07-24T00:00:00Z