Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia. - Wikidata - wikimedia - TriplyDB

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

http://www.wikidata.org/entity/Q37230559

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Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.Functional osteoclast attachment requires inositol-1,4,5-trisphosphate receptor-associated cGMP-dependent kinase substrate.Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation.Sustained release of adiponectin improves osteogenesis around hydroxyapatite implants by suppressing osteoclast activity in ovariectomized rabbits Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation.Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis.c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes Regulation of osteoclast function.The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation.Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines.Adenoviral vector-mediated overexpression of osteoprotegerin accelerates osteointegration of titanium implants in ovariectomized rats.Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.The actin-binding protein PPP1r18 regulates maturation, actin organization, and bone resorption activity of osteoclasts.[Implication of the ubiquitin ligase c-Cbl in bone formation and tumorigenesis].

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Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

http://www.wikidata.org/entity/Q37230559

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@en

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

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type

label

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@en

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@nl

prefLabel

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@en

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@nl

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Journal of Bone and Mineral Research

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Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia.

@en

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Arata Nakajima

http://www.w3.org/2001/XMLSchema#string

Archana Sanjay

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Cecile Itzsteink

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Lynn Neff

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Naga Suresh Adapala

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Riccardo Chiusaroli

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Roland Baron

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William C Horne

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P2860

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts

CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl

Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

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1162-1172

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scholarly article

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10.1359/JBMR.090205

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7

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24

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2009-07-01T00:00:00Z

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24174151

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19257814

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2697622

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