A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.
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TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive HematopoiesisOceans of opportunity: exploring vertebrate hematopoiesis in zebrafishEssential role of c-myb in definitive hematopoiesis is evolutionarily conserved.Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish modelsSpatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation.Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells.Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families.Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.cpsf1 is required for definitive HSC survival in zebrafish.A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.Clonal analysis of hematopoietic progenitor cells in the zebrafish.Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cellsMutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisitionTranscriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia.In vivo chemical screening for modulators of hematopoiesis and hematological diseasesMyb proteins: angels and demons in normal and transformed cells.Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning.Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control.Hematopoietic stem cell emergence in the conceptus and the role of Runx1.Epigenetics, development, and cancer: zebrafish make their mark..In vivo imaging of hematopoietic stem cell development in the zebrafish.Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.A network of epigenetic regulators guides developmental haematopoiesis in vivo.Complex regulation of HSC emergence by the Notch signaling pathway.Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.Myelopoiesis and myeloid leukaemogenesis in the zebrafish.Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish.Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs.Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b.Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects.Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation.Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence.Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.Conformation Dynamics of the Intrinsically Disordered Protein c-Myb with the ff99IDPs Force Field.A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.
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A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 30 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@en
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@nl
type
label
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@en
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@nl
prefLabel
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@en
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@nl
P2093
P2860
P1433
P1476
A genetic screen in zebrafish ...... topoietic stem cell emergence.
@en
P2093
Adam H Amsterdam
Alexandra C H Smith
Caroline E Burns
Elizabeth A Mayhall
Elizabeth J Paik
Jenna L Galloway
Leonard I Zon
Matthew D Keefe
Timothy J Cashman
P2860
P304
P356
10.1182/BLOOD-2008-12-193607
P407
P577
2009-03-30T00:00:00Z