The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.
about
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitorNegative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase AExpression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissuesHistone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradationHDAC8 substrates: Histones and beyondLysine deacetylase (KDAC) regulatory pathways: an alternative approach to selective modulationHistone deacetylases and cancerHDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeuticsMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitCbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.Core-binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapy.Role of AML1/Runx1 in the pathogenesis of hematological malignancies.HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice.Histone Deacetylases in Bone Development and Skeletal Disorders.HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 AcetylationFLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors GranulopoiesisChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesisThe transcriptional repressor NKAP is required for the development of iNKT cellsRegain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibitionInhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages.A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiationCore binding factor at the crossroads: determining the fate of the HSC.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.The molecular signature of oncofusion proteins in acute myeloid leukemia.Dynamics of epigenetic modifications in leukemia.Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival.Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages.Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.
P2860
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P2860
The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The inv(16) fusion protein ass ...... scle myosin heavy-chain domain
@nl
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@ast
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@en
type
label
The inv(16) fusion protein ass ...... scle myosin heavy-chain domain
@nl
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@ast
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@en
prefLabel
The inv(16) fusion protein ass ...... scle myosin heavy-chain domain
@nl
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@ast
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@en
P2093
P2860
P1476
The inv(16) fusion protein ass ...... cle myosin heavy-chain domain.
@en
P2093
Alan D Friedman
Bart Lutterbach
Kristie L Durst
Scott W Hiebert
Tanawan Kummalue
P2860
P304
P356
10.1128/MCB.23.2.607-619.2003
P407
P577
2003-01-01T00:00:00Z