A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
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Recent progress in structure-based anti-influenza drug designM2 protein from influenza A: from multiple structures to biophysical and functional insightsThe p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channelsStructure of the amantadine binding site of influenza M2 proton channels in lipid bilayersInsight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid BilayerHigh-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transductionStudy on phylogenetic relationships, variability, and correlated mutations in M2 proteins of influenza virus ADrug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins.Magic angle spinning and oriented sample solid-state NMR structural restraints combine for influenza a M2 protein functional insights.Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.Conformational heterogeneity of the M2 proton channel and a structural model for channel activationConformational changes of an ion channel detected through water-protein interactions using solid-state NMR spectroscopy.Theoretical frameworks for multiscale modeling and simulationMechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMRA theory for the proton transport of the influenza virus M2 protein: extensive test against conductance dataMultiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel.Proton Transport Mechanism of M2 Proton Channel Studied by Laser-Induced pH JumpDiffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site.Proton and cation transport activity of the M2 proton channel from influenza A virus.Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers.Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virusThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesInfluence of solubilizing environments on membrane protein structuresEffect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza A protein M2 in cell-free membrane patches of Xenopus oocytesM2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activityMolecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular SimulationsIdentification of the functional core of the influenza A virus A/M2 proton-selective ion channelActivation and proton transport mechanism in influenza A M2 channelAcid activation mechanism of the influenza A M2 proton channel.Binding hot spots and amantadine orientation in the influenza a virus M2 proton channelStructure and function of the influenza A M2 proton channelFlu channel drug resistance: a tale of two sites.Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.Decoupled side chain and backbone dynamics for proton translocation - M2 of influenza A.Conformational Activation of a Transmembrane Proton Channel from Constant pH Molecular Dynamics.Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus
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A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@en
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@nl
type
label
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@en
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@nl
prefLabel
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@en
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.
@nl
P2860
P356
P1476
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine
@en
P2093
Myunggi Yi
Timothy A Cross
P2860
P304
P356
10.1021/JP800171M
P407
P577
2008-05-14T00:00:00Z