α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. - Wikidata - wikimedia - TriplyDB

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.

http://www.wikidata.org/entity/Q37242415

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Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Protein misfolding in neurodegenerative diseases: implications and strategies.Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms.α-Synuclein and Parkinsonism: Updates and Future Perspectives.The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.Resveratrol and Brain Mitochondria: a Review.Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease Top Altmetric Scores in the Parkinson's Disease Literature αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Progress toward an integrated understanding of Parkinson's disease.Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy.A functional connection between dyskerin and energy metabolism.Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.Oxidative stress and cellular pathologies in Parkinson's disease.Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models.Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease.Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.An in vitro model yields 'importin' new insights into chronic traumatic encephalopathy: damaged astrocytes stop 'thrombospondin' to the injury: An Editorial Highlight for 'Defective synthesis and release of astrocytic thrombospondin-1 mediates the n In Situ Proximity Ligation Assay Reveals Co-Localization of Alpha-Synuclein and SNARE Proteins in Murine Primary Neurons.Current perspective of mitochondrial biology in Parkinson's disease.Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.

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α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.

http://www.wikidata.org/entity/Q37242415

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on June 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@en

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@nl

type

label

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@en

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@nl

prefLabel

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@en

α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

@nl

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SCITRANSLMED.AAF3634

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Science Translational Medicine

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α-Synuclein binds to TOM20 and ...... import in Parkinson's disease.

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Alevtina Zharikov

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Caitlyn W Barrett

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Eric K Hoffman

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J Timothy Greenamyre

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Jennifer McCoy

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Paul J Barrett

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Roberto Di Maio

http://www.w3.org/2001/XMLSchema#string

Teresa G Hastings

http://www.w3.org/2001/XMLSchema#string

Xiaoping Hu

http://www.w3.org/2001/XMLSchema#string

P2860

Rotenone, paraquat, and Parkinson's disease

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

A highly reproducible rotenone model of Parkinson's disease

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

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342ra78

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scholarly article

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10.1126/SCITRANSLMED.AAF3634

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P433

342

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8

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Charleen T. Chu

Edward A Burton

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2016-06-01T00:00:00Z

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27280685

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Parkinson's disease

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5016095

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