Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
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Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridgeSpecificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse flyBiochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinasesA Novel Allosteric Inhibitor of the Uridine Diphosphate N -Acetylglucosamine Pyrophosphorylase from Trypanosoma bruceiPIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols.Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi.Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei.GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida.Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A.Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness.Bioinformatics and functional analysis of an Entamoeba histolytica mannosyltransferase necessary for parasite complement resistance and hepatical infection.Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetseSynthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei.Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it.Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana.Secretory pathway of trypanosomatid parasites.Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal ActivityEssential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surfaceIdentification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins.GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesisGlycosyl phosphatidylinositol-anchored proteins in chemosensory signaling: antisense manipulation of Paramecium tetraurelia PIG-A gene expression.Transcriptional Profiling the 150 kb Linear Megaplasmid of Borrelia turicatae Suggests a Role in Vector Colonization and Initiating Mammalian Infection.A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis.Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunitsGlycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sicknessSurface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors.GPI-anchored protein organization and dynamics at the cell surface.Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review].The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids.Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.Assembly of a Complex Branched Oligosaccharide by Combining Fluorous-Supported Synthesis and Stereoselective Glycosylations using Anomeric Sulfonium Ions
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P2860
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2000
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
@en
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.
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Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
@en
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.
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prefLabel
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
@en
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.
@nl
P2093
P2860
P921
P356
P1476
Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
@en
P2093
Kinoshita T
Nagamune K
Schwarz RT
Sutterlin C
P2860
P304
10336-10341
P356
10.1073/PNAS.180230697
P407
P577
2000-09-01T00:00:00Z