Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry.
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In vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage productsBioanalytical determination of unstable endogenous small peptides: RFRP3 and its metabolites in rat blood.Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies.Direct quantification of lipopeptide biosurfactants in biological samples via HPLC and UPLC-MS requires sample modification with an organic solvent.Critical topics in ensuring data quality in bioanalytical LC-MS method development.Validation of a bioanalytical method for the quantification of a therapeutic peptide, ramoplanin, in human dried blood spots using LC-MS/MS.An improved LC-MS/MS method for the determination of taspoglutide in plasma and urine using orthogonal HILIC-RP column switching, ultra-performance LC separation and 'wrong-way-round' electrospray ionization.Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges.Neuropeptide analysis with liquid chromatography-capillary electrophoresis-mass spectrometric imaging.Qualification and application of a liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of trastuzumab in rat plasma.A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma.LR12-peptide quantitation in whole blood by RP-HPLC and intrinsic fluorescence detection: Validation and pharmacokinetic study.Evaluation of protein quantification using standard peptides containing single conservative amino acid replacementsRecommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based AssaysImproved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenateAdvances in bioanalytical LC-MS using the Orbitrap™ mass analyzer.Fast liquid chromatography combined with mass spectrometry for the analysis of metabolites and proteins in human body fluids.Unique challenges of providing bioanalytical support for biological therapeutic pharmacokinetic programs.The absolute quantification of endogenous levels of brain neuropeptides in vivo using LC-MS/MS.Bioanalytical approaches to analyzing peptides and proteins by LC--MS/MS.Peptide and protein drugs: the study of their metabolism and catabolism by mass spectrometry.MS-based approaches to unravel the molecular complexity of proprotein-derived biomarkers and support their quantification: the examples of B-type natriuretic peptide and apelin peptides.Advances in the quantitation of therapeutic insulin analogues by LC-MS/MS.Sensitive glucagon quantification by immunochemical and LC-MS/MS methods.LC-MS/MS in endocrinology: what is the profit of the last 5 years?Current trends in mass spectrometry of peptides and proteins: Application to veterinary and sports-doping control.Application and challenges in using LC-MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery.Strategic approaches to optimizing peptide ADME propertiesNewly introduced sample preparation techniques: towards miniaturization.Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays.LC-MS-based quantification of intact proteins: perspective for clinical and bioanalytical applications.An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.Digestion, Purification, and Enrichment of Protein Samples for Mass Spectrometry.Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping.Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study.Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples.Quantification of ghrelin and des-acyl ghrelin in human plasma by using cubic-selected reaction-monitoring LCMS.LC-MS/MS quantification of parathyroid hormone fragment 1-34 in human plasma.Large-molecule quantification: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF.Direct quantitative analysis of a 20 kDa PEGylated human calcitonin gene peptide antagonist in cynomolgus monkey serum using in-source CID and UPLC-MS/MS.
P2860
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P2860
Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 26 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Quantitative bioanalysis of pe ...... to (tandem) mass spectrometry.
@en
Quantitative bioanalysis of peptides by liquid chromatography coupled to
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type
label
Quantitative bioanalysis of pe ...... to (tandem) mass spectrometry.
@en
Quantitative bioanalysis of peptides by liquid chromatography coupled to
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prefLabel
Quantitative bioanalysis of pe ...... to (tandem) mass spectrometry.
@en
Quantitative bioanalysis of peptides by liquid chromatography coupled to
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P2093
P1476
Quantitative bioanalysis of pe ...... to (tandem) mass spectrometry.
@en
P2093
Irene van den Broek
Jan H M Schellens
Jos H Beijnen
Rolf W Sparidans
P356
10.1016/J.JCHROMB.2008.07.021
P577
2008-07-26T00:00:00Z