APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
about
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentControl of cell growth by the SCF and APC/C ubiquitin ligasesAn Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant GliomaBub3 promotes Cdc20-dependent activation of the APC/C in S. cerevisiae.Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationThe APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localizationInduction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydesThe APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitMolecular basis of APC/C regulation by the spindle assembly checkpoint.cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytesMutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegansSubstrate degradation by the anaphase promoting complex occurs during mitotic slippage.An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitinationThe APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisMad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregationRoles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly.Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesisSpindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferationDependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.Role of ubiquitination in meiotic recombination repair.Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy.Processive ubiquitin chain formation by the anaphase-promoting complex.The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.Panta rhei: the APC/C at steady state.Cdc20 control of cell fate during prolonged mitotic arrest: do Cdc20 protein levels affect cell fate in response to antimitotic compounds?Sequential loss of cell cycle checkpoint control contributes to malignant transformation of murine embryonic fibroblasts induced by 20-methylcholanthrene.High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer.Cdc20 proteolysis requires p38 MAPK signaling and Cdh1-independent APC/C ubiquitination during spindle assembly checkpoint activation by cadmium.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.The end of mitosis from a phosphatase perspective.Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1Cell Cycle Control by Nuclear Sequestration of CDC20 and CDH1 mRNA in Plant Stem Cells.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
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APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@en
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@nl
type
label
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@en
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@nl
prefLabel
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@en
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.
@nl
P2860
P356
P1433
P1476
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation
@en
P2093
Jeffrey R Skaar
P2860
P304
P356
10.4161/CC.8.1.7606
P577
2009-01-11T00:00:00Z