SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseNumb activates the E3 ligase Itch to control Gli1 function through a novel degradation signalRepeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionCheckpoint recovery in cells: how a molecular understanding can help in the fight against cancerProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressThe F-box protein FBXO45 promotes the proteasome-dependent degradation of p73ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage responseThe Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointThe ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survivalControl of cell growth by the SCF and APC/C ubiquitin ligasesDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinInsights into APC/C: from cellular function to diseases and therapeuticsMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationRecovery from the DNA Replication CheckpointDNA damage control: regulation and functions of checkpoint kinase 1Ubiquitylation, neddylation and the DNA damage responsePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionmTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTORNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Control of chromosome stability by the beta-TrCP-REST-Mad2 axisUbiquitination and degradation of the inhibitors of NF-kappaBRhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damagemiR-24 triggers epidermal differentiation by controlling actin adhesion and cell migrationRoles of Chk1 in cell biology and cancer therapyPhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointRegulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neuronsWrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationAtaxin-3 promotes genome integrity by stabilizing Chk1.Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidyIKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.Cullins and cancer.Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.
P2860
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P248
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P2860
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@ast
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en-gb
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@nl
type
label
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@ast
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en-gb
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@nl
prefLabel
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@ast
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en-gb
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@nl
P2093
P50
P921
P3181
P1433
P1476
SCFbetaTrCP-mediated degradati ...... eplication checkpoint response
@en
P2093
Monica Venere
N Valerio Dorrello
Thanos Halazonetis
P304
P3181
P356
10.1016/J.MOLCEL.2006.06.013
P407
P577
2006-08-04T00:00:00Z