Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.
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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organismsThe E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in miceRegulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in micePinX1: a sought-after major tumor suppressor at human chromosome 8p23Adrenocortical stem and progenitor cells: implications for adrenocortical carcinomaTowards an understanding of the role of p53 in adrenocortical carcinogenesis.Animal models of adrenocortical tumorigenesisDevelopment of adrenal cortex zonation.Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype.Mouse models of adrenocortical tumors.The shelterin complex and hematopoiesis.Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.Telomeres and telomerase in cancerHematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.Defending the end zone: studying the players involved in protecting chromosome endsAdrenocortical growth and cancer.Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.Telomere-driven diseases and telomere-targeting therapies.Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres.Structural and functional association of androgen receptor with telomeres in prostate cancer cells.Androgen receptor interacts with telomeric proteins in prostate cancer cells.The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.Telomeres: Implications for Cancer Development.
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P2860
Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@en
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
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type
label
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@en
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@nl
prefLabel
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@en
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@nl
P2093
P2860
P1433
P1476
Genetic p53 deficiency partial ...... se of increased tumorigenesis.
@en
P2093
Alessia Trovato
Alex C Kim
David O Ferguson
Gary D Hammer
Peter C Lucas
Rork D Kuick
Tobias Else
P2860
P304
P356
10.1016/J.CCR.2009.04.011
P577
2009-06-01T00:00:00Z