Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. - Wikidata - wikimedia - TriplyDB

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.

http://www.wikidata.org/entity/Q37245378

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Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice PinX1: a sought-after major tumor suppressor at human chromosome 8p23 Adrenocortical stem and progenitor cells: implications for adrenocortical carcinoma Towards an understanding of the role of p53 in adrenocortical carcinogenesis.Animal models of adrenocortical tumorigenesis Development of adrenal cortex zonation.Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype.Mouse models of adrenocortical tumors.The shelterin complex and hematopoiesis.Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.Telomeres and telomerase in cancer Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.Defending the end zone: studying the players involved in protecting chromosome ends Adrenocortical growth and cancer.Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.Telomere-driven diseases and telomere-targeting therapies.Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres.Structural and functional association of androgen receptor with telomeres in prostate cancer cells.Androgen receptor interacts with telomeric proteins in prostate cancer cells.The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.Telomeres: Implications for Cancer Development.

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Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.

http://www.wikidata.org/entity/Q37245378

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on June 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@en

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

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type

label

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@en

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@nl

prefLabel

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@en

Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@nl

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J.CCR.2009.04.011

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Genetic p53 deficiency partial ...... se of increased tumorigenesis.

@en

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Alessia Trovato

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Alex C Kim

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David O Ferguson

http://www.w3.org/2001/XMLSchema#string

Gary D Hammer

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Peter C Lucas

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Rork D Kuick

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Tobias Else

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Yipin Wu

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P2860

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

PTOP interacts with POT1 and regulates its localization to telomeres

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

Tpp1/Acd maintains genomic stability through a complex role in telomere protection

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

Telomere protection by mammalian Pot1 requires interaction with Tpp1

Wild-derived inbred mouse strains have short telomeres.

TRF2 Protects Human Telomeres from End-to-End Fusions

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465-476

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scholarly article

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10.1016/J.CCR.2009.04.011

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6

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15

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2009-06-01T00:00:00Z

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26248638

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19477426

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2703790

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