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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaCharacterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cellsJdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosityNotch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomasThe novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancersFocused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemiaCross-talk between miRNA and Notch signaling pathways in tumor development and progression.Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells.Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling.A central role for Notch in effector CD8(+) T cell differentiationNotch is oncogenic dominant in T-cell acute lymphoblastic leukemia.Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemiaNotch signaling proteins: legitimate targets for cancer therapy.Assembly of a Notch transcriptional activation complex requires multimerization.Regulator of myeloid differentiation and function: The secret life of Ikaros.IFN-γ promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation.Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion RadiotherapySequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.The two faces of FBW7 in cancer drug resistance.Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphomamicroRNA signature for human pancreatic cancer invasion and metastasis.α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levelsMultifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.Notch1 signaling is involved in regulating Foxp3 expression in T-ALL.NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia.Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERKDual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.Mind bomb 1 regulation of cFLIP interactions.Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain.Ikaros in immune receptor signaling, lymphocyte differentiation, and function.Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies.Notch signalling in solid tumours: a little bit of everything but not all the time.Notch signaling in cardiac valve development and disease.p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies.T-cell acute lymphoblastic leukaemia: recent molecular biology findings.Genomic characterization of acute leukemias.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
It's T-ALL about Notch.
@en
It's T-ALL about Notch.
@nl
type
label
It's T-ALL about Notch.
@en
It's T-ALL about Notch.
@nl
prefLabel
It's T-ALL about Notch.
@en
It's T-ALL about Notch.
@nl
P2093
P2860
P356
P1433
P1476
It's T-ALL about Notch.
@en
P2093
A J Capobianco
R M Demarest
P2860
P2888
P304
P356
10.1038/ONC.2008.222
P407
P577
2008-09-01T00:00:00Z