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Extracellular hemin crisis triggers acute chest syndrome in sickle mice

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

http://www.wikidata.org/entity/Q37259191

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Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors.Morphine for the treatment of pain in sickle cell disease Advances in sickle cell therapies in the hydroxyurea era Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development Protein aggregation as a cellular response to oxidative stress induced by heme and iron Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice.Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.Rapidly progressive acute chest syndrome in individuals with sickle cell anemia: a distinct acute chest syndrome phenotype.Atherogenesis and iron: from epidemiology to cellular level.Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor Hemolysis-induced lethality involves inflammasome activation by heme Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation.Iron, inflammation, and early death in adults with sickle cell disease.Vasculopathy and pulmonary hypertension in sickle cell disease.Role of heme in cardiovascular physiology and disease.Excess of heme induces tissue factor-dependent activation of coagulation in mice.Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress Heme-related molecules induce rapid production of neutrophil extracellular traps.Hemopexin in severe inflammation and infection: mouse models and human diseases Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease.Melanoma tumor growth is accelerated in a mouse model of sickle cell disease.Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia.Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)Inflammatory targets of therapy in sickle cell disease.Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia.Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology.Pathophysiology and treatment of pulmonary hypertension in sickle cell disease Cell-free hemoglobin: a novel mediator of acute lung injury Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response.Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice.Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model.The heart in sickle cell disease, a model for heart failure with preserved ejection fraction Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease.

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P2860

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

http://www.wikidata.org/entity/Q37259191

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

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2013年學術文章

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name

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice.

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type

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice.

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice

@en

Extracellular hemin crisis triggers acute chest syndrome in sickle mice.

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Journal of Clinical Investigation

P1476

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

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P2093

David Robert Archer

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Fang Tan

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Kesmic Ann Jackson

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Olufolake Adetoro Adisa

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Prasanthi Chappa

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P2860

COMMD proteins, a novel family of structural and functional homologs of MURR1

A central role for free heme in the pathogenesis of severe sepsis

Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease.

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

The acute chest syndrome in sickle cell disease. Possible role of nitric oxide in its pathophysiology and treatment.

Reconstructing sickle cell disease: a data-based analysis of the "hyperhemolysis paradigm" for pulmonary hypertension from the perspective of evidence-based medicine.

Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease.

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11

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Solomon F Ofori-Acquah

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257301050

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