The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations
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Protein-induced photophysical changes to the amyloid indicator dye thioflavin TMinimalist design of water-soluble cross-beta architecture.Molecular mechanism of Thioflavin-T binding to amyloid fibrilsBinding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current statusThermodynamic selection of steric zipper patterns in the amyloid cross-beta spineMolecular dynamics simulations of anti-aggregation effect of ibuprofen.Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining AmyloidogenicitySpectroscopic Characterization of Intermolecular Interaction of Amyloid β Promoted on GM1 Micelles.On the origin of the stronger binding of PIB over thioflavin T to protofibrils of the Alzheimer amyloid-β peptide: a molecular dynamics study.Binding of nonsteroidal anti-inflammatory drugs to Abeta fibrilStructural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growthExploring the influence of carbon nanoparticles on the formation of β-sheet-rich oligomers of IAPP₂₂₋₂₈ peptide by molecular dynamics simulation.Insight into amyloid structure using chemical probes.Direct observation of morphological transformation from twisted ribbons into helical ribbonsIntermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin.Binding of Congo red to amyloid protofibrils of the Alzheimer Aβ(9-40) peptide probed by molecular dynamics simulations.Ligand electronic properties modulate tau filament binding site densityWhat amyloid ligands can tell us about molecular polymorphism and disease.Modulation and detection of tau aggregation with small-molecule ligandsMolecular dynamics simulations of Ibuprofen binding to Abeta peptidesDual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding ProteinsObservation of molecular inhibition and binding structures of amyloid peptides.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseMetal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.Benzothiazole-Based Neutral Ratiometric Fluorescence Sensor for Amyloid Fibrils.Oligovalent amyloid-binding agents reduce SEVI-mediated enhancement of HIV-1 infection.QSAR studies for prediction of cross-β sheet aggregate binding affinity and selectivityMolecular interactions of Alzheimer's biomarker FDDNP with Aβ peptide.Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitorPolarized super-resolution structural imaging inside amyloid fibrils using Thioflavine T.Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy.Specific in situ discrimination of amyloid fibrils versus α-helical fibres by the fluorophore NIAD-4.Molecular level studies on binding modes of labeling molecules with polyalanine peptides.An adaptive bias - hybrid MD/kMC algorithm for protein folding and aggregation.Iron Oxide Nanoparticles Labeled with an Excited-State Intramolecular Proton Transfer Dye.Nucleation of Amyloid Oligomers by RepA-WH1-Prionoid-Functionalized Gold Nanorods.Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.Molecular insight into amyloid oligomer destabilizing mechanism of flavonoid derivative 2-(4′ benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and molecular dynamics simulations
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The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 07 October 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The binding of thioflavin T an ...... the Alzheimer's disease Abeta
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The binding of thioflavin T an ...... molecular dynamics simulations
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type
label
The binding of thioflavin T an ...... the Alzheimer's disease Abeta
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The binding of thioflavin T an ...... molecular dynamics simulations
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prefLabel
The binding of thioflavin T an ...... the Alzheimer's disease Abeta
@nl
The binding of thioflavin T an ...... molecular dynamics simulations
@en
P2093
P2860
P1476
The binding of thioflavin T an ...... molecular dynamics simulations
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P2093
Hongxing Lei
Joan-Emma Shea
Michael T Bowers
Zhixiang Wang
P2860
P304
P356
10.1016/J.JMB.2008.09.062
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P50
P577
2008-10-07T00:00:00Z