Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
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Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heartIn obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidationObesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study.Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart.Mitochondrial and cellular mechanisms for managing lipid excess.Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activityCardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticityHypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndromeChemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle.High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production.Updating experimental models of diabetic cardiomyopathyIntramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunctionCardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophyInfluence of dark phase restricted high fat feeding on myocardial adaptation in miceMolecular and metabolic mechanisms of cardiac dysfunction in diabetes.Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease.The impact of current and novel anti-diabetic therapies on cardiovascular risk.Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria.Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes.Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress.Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models.Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.Transcriptome changes favoring intramuscular fat deposition in the longissimus muscle following castration of bulls.FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model.Catalase-dependent H2O2 consumption by cardiac mitochondria and redox-mediated loss in insulin signaling.Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction.Malonyl CoA: A promising target for the treatment of cardiac disease.Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.
P2860
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P2860
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@en
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@nl
type
label
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@en
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@nl
prefLabel
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@en
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@nl
P2093
P2860
P921
P356
P1433
P1476
Insulin-stimulated cardiac glu ...... ing malonyl CoA decarboxylase.
@en
P2093
Gary D Lopaschuk
Jagdip S Jaswal
Jason R B Dyck
John R Ussher
Liyan Zhang
Olga Ilkayeva
Timothy R Koves
P2860
P304
P356
10.2337/DB09-0011
P407
P577
2009-05-28T00:00:00Z