Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells. - Wikidata - wikimedia - TriplyDB

Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells.

Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells.

http://www.wikidata.org/entity/Q37269119

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pH sensing and regulation in cancer Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases Models for the a subunits of the Thermus thermophilus V/A-ATPase and Saccharomyces cerevisiae V-ATPase enzymes by cryo-EM and evolutionary covariance TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression Major cellular and physiological impacts of ocean acidification on a reef building coral A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.Regulation and isoform function of the V-ATPases.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G.Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy.The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells.Molecular characterization and serological reactivity of a vacuolar ATP synthase subunit ε-like protein from Clonorchis sinensis.Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase.Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression.Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer Drug resistance and cellular adaptation to tumor acidic pH microenvironment Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor.The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells Regulation of luminal acidification by the V-ATPase.The Function of V-ATPases in Cancer The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.Structural analysis of the N-terminal domain of subunit a of the yeast vacuolar ATPase (V-ATPase) using accessibility of single cysteine substitutions to chemical modification.Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling.Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy.

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Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells.

http://www.wikidata.org/entity/Q37269119

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 14 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Function of a subunit isoforms ...... 231 human breast cancer cells.

@en

Function of a subunit isoforms ...... 231 human breast cancer cells.

@nl

type

label

Function of a subunit isoforms ...... 231 human breast cancer cells.

@en

Function of a subunit isoforms ...... 231 human breast cancer cells.

@nl

prefLabel

Function of a subunit isoforms ...... 231 human breast cancer cells.

@en

Function of a subunit isoforms ...... 231 human breast cancer cells.

@nl

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Function of a subunit isoforms ...... 231 human breast cancer cells.

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Ayana Hinton

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Daniel Jay

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G Gary Sahagian

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Michael Forgac

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Min Fang

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Moshe Reuveni

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Raul Martinez-Zaguilan

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Sarah Bond

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Souad R Sennoune

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P2860

Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.

STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p.

The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.

Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis

Mannose 6-phosphate receptors: new twists in the tale

Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis

a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit a

Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene

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10.1074/JBC.M901201200

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