Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. - Wikidata - wikimedia - TriplyDB

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.

http://www.wikidata.org/entity/Q37271051

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Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells Lestaurtinib, a multitargeted tyrosine kinase inhibitor: from bench to bedside.FLT3-regulated antigens as targets for leukemia-reactive cytotoxic T lymphocytes.Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis Survivin selectively modulates genes deregulated in human leukemia stem cells.Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1 Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner.Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models.Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML Cytoplasmic localization of wild-type survivin is associated with constitutive activation of the PI3K/Akt signaling pathway and represents a favorable prognostic factor in patients with acute myeloid leukemia.Graft-versus-leukemia effect of nonmyeloablative stem cell transplantation.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.Overexpression of survivin initiates hematologic malignancies in vivo Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation.

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Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.

http://www.wikidata.org/entity/Q37271051

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

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Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

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type

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Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

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Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

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prefLabel

Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

@en

Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

@nl

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BLOOD-2008-11-188714

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Survivin mediates aberrant hem ...... al tandem duplication of Flt3.

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Akira Moh

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Edward M Conway

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H Scott Boswell

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Louis M Pelus

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Mariko Abe

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Pratibha Singh

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Seiji Fukuda

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Seiji Yamaguchi

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Xin-Yuan Fu

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P2860

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An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

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Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

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394-403

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scholarly article

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10.1182/BLOOD-2008-11-188714

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19411632

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