P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.
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Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic responseBreast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic PhenotypeGiant Lysosomes as a Chemotherapy Resistance Mechanism in Hepatocellular Carcinoma CellsPhotoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition.Regulated lysosomal exocytosis mediates cancer progressionUnraveling the mysteries of serum albumin-more than just a serum protein.Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction.Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells.Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic fluxA2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrierReversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles.Role of gambogic acid and NaI131 in A549/DDP cells.A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.Exosome: emerging biomarker in breast cancer.Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?Nedaplatin sensitization of cisplatin-resistant human non-small cell lung cancer cells.Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis.Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression.Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.Helicobacter pylori modulates cisplatin sensitivity in gastric cancer by down-regulating miR-141 expression.Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers.LysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance.A hindsight reflection on the clinical studies of poly(l-glutamic acid)-paclitaxel.Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.The novel strategies for next-generation cancer treatment: miRNA combined with chemotherapeutic agents for the treatment of cancer.Acid-sensitive lipidated doxorubicin prodrug entrapped in nanoemulsion impairs lung tumor metastasis in a breast cancer model.Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins.Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
P2860
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P2860
P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 September 2013
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@en
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@nl
type
label
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@en
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@nl
prefLabel
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@en
P-glycoprotein mediates drug r ...... lving lysosomal sequestration.
@nl
P2093
P2860
P356
P1476
P-glycoprotein mediates drug r ...... olving lysosomal sequestration
@en
P2093
Akanksha Arvind
Danae M Sharp
Patric J Jansson
Tetsuo Yamagishi
P2860
P304
31761-31771
P356
10.1074/JBC.M113.514091
P407
P577
2013-09-23T00:00:00Z