Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
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Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemiasAssociation of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell linesAML1 interconnected pathways of leukemogenesisSUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivoInteractions between the leukaemia-associated ETO homologues of nuclear repressor proteinsAccelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survivalAML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance.AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation.The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Molecular and clinical advances in core binding factor primary acute myeloid leukemia: a paradigm for translational research in malignant hematology.Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionAML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Class III receptor tyrosine kinases: role in leukaemogenesis.The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genesNew mechanisms of AML1 gene alteration in hematological malignancies.The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice.Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesisNew insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.Chromosomal aberrations and fusion genes in myeloid malignancies.Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit.The role of TLE1 in synovial sarcoma.The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Epigenetic consequences of AML1-ETO action at the human c-FMS locus.Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha.Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells.
P2860
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P2860
Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Synergistic up-regulation of t ...... tor receptor by AML1 and the t
@nl
Synergistic up-regulation of t ...... contribute to leukemogenesis.
@en
type
label
Synergistic up-regulation of t ...... tor receptor by AML1 and the t
@nl
Synergistic up-regulation of t ...... contribute to leukemogenesis.
@en
prefLabel
Synergistic up-regulation of t ...... tor receptor by AML1 and the t
@nl
Synergistic up-regulation of t ...... contribute to leukemogenesis.
@en
P2093
P2860
P356
P1476
Synergistic up-regulation of t ...... contribute to leukemogenesis.
@en
P2093
C J Hetherington
G Nucifora
J D Rowley
K L Rhoades
S W Hiebert
P2860
P304
11895-11900
P356
10.1073/PNAS.93.21.11895
P407
P577
1996-10-01T00:00:00Z