Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. - Wikidata - wikimedia - TriplyDB

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

http://www.wikidata.org/entity/Q39576827

about

SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein The histone deacetylase 9 gene encodes multiple protein isoforms Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1 Transcriptional repression by the insulator protein CTCF involves histone deacetylases The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor Cloning and characterization of a novel human histone deacetylase, HDAC8 Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes Nuclear receptor corepressors Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors ETO2 coordinates cellular proliferation and differentiation during erythropoiesis ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain Oligomerization of ETO is obligatory for corepressor interaction BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications Identification of AML1-ETO modulators by chemical genomics Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia PLZF is a negative regulator of retinoic acid receptor transcriptional activity The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells Aberrant CBFA2T3B gene promoter methylation in breast tumors Interplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in Leukemia Transcriptional network control of normal and leukaemic haematopoiesis New and emerging HDAC inhibitors for cancer treatment Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery Structural and Functional Analysis of the DEAF-1 and BS69 MYND Domains A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

http://www.wikidata.org/entity/Q39576827

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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1998年论文

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1998年论文

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name

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@en

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

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type

label

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@en

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@nl

prefLabel

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@en

Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@nl

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Molecular and Cellular Biology

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Aberrant recruitment of the nu ...... d leukemia fusion partner ETO.

@en

P2093

J Zhang

http://www.w3.org/2001/XMLSchema#string

M A Lazar

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M Fanelli

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P G Pelicci

http://www.w3.org/2001/XMLSchema#string

S Minucci

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V Gelmetti

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P2860

The TAF(II)250 subunit of TFIID has histone acetyltransferase activity

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

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7185-7191

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10.1128/MCB.18.12.7185

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12

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18

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9819405

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109300

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