Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA. - Wikidata - wikimedia - TriplyDB

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

http://www.wikidata.org/entity/Q37277024

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Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation.How theories evolved concerning the mechanism of action of barbiturates.Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors Pharmacology of structural changes at the GABA(A) receptor transmitter binding site.Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.New insights into the molecular mechanisms of general anaesthetics.Insights into the structure and pharmacology of GABA(A) receptors.Activation of alpha6-containing GABAA receptors by pentobarbital occurs through a different mechanism than activation by GABA.Cortical neurons and networks are dormant but fully responsive during isoelectric brain state.Excitability and responsiveness of rat barrel cortex neurons in the presence and absence of spontaneous synaptic activity in vivo.

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Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

http://www.wikidata.org/entity/Q37277024

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@en

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@nl

type

label

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@en

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@nl

prefLabel

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@en

Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@nl

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J.BPJ.2008.09.037

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Biophysical Journal

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Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.

@en

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Cassandra M Theusch

http://www.w3.org/2001/XMLSchema#string

Cynthia Czajkowski

http://www.w3.org/2001/XMLSchema#string

Meyer B Jackson

http://www.w3.org/2001/XMLSchema#string

Yukiko Muroi

http://www.w3.org/2001/XMLSchema#string

P2860

Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment

Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Structure and gating mechanism of the acetylcholine receptor pore

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

Coupling of agonist binding to channel gating in the GABA(A) receptor.

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499-509

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scholarly article

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10.1016/J.BPJ.2008.09.037

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2

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96

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2009-01-01T00:00:00Z

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23937614

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19167300

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2716461

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