Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.
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A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptorsCrystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding ProteinMolecular sites for the positive allosteric modulation of glycine receptors by endocannabinoidsFluorescence applications in molecular neurobiologyMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.Glycine receptor mouse mutants: model systems for human hyperekplexiaGlycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptorsA cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.Contributions of conserved residues at the gating interface of glycine receptors.Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptorPredicting flexible loop regions that interact with ligands: the challenge of accurate scoringZolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptorsRegulation of the surface expression of α4β2δ GABAA receptors by high efficacy statesDistinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric proteinSubunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.String method solution of the gating pathways for a pentameric ligand-gated ion channel.Glucose is a positive modulator for the activation of human recombinant glycine receptors.
P2860
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P2860
Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Magnitude of a conformational ...... related with agonist efficacy.
@en
Magnitude of a conformational ...... related with agonist efficacy.
@nl
type
label
Magnitude of a conformational ...... related with agonist efficacy.
@en
Magnitude of a conformational ...... related with agonist efficacy.
@nl
prefLabel
Magnitude of a conformational ...... related with agonist efficacy.
@en
Magnitude of a conformational ...... related with agonist efficacy.
@nl
P2860
P356
P1476
Magnitude of a conformational ...... related with agonist efficacy.
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P2093
Joseph W Lynch
P2860
P304
27370-27376
P356
10.1074/JBC.M109.048405
P407
P577
2009-07-30T00:00:00Z