IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma. - Wikidata - wikimedia - TriplyDB

IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.

IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.

http://www.wikidata.org/entity/Q37278507

about

The Complex Role of STAT3 in Viral Infections The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.A novel role for IL-22R1 as a driver of inflammation.Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.JAK Kinases in Health and Disease: An Update Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis.JAK3: a two-faced player in hematological disorders Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies New developments in the pathology of malignant lymphoma: a review of the literature published from January to August 2009.JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.Interleukin-12: clinical usage and molecular markers of cancer susceptibility.The pathobiology of the oncogenic tyrosine kinase NPM-ALK: a brief update.Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma.IL-21: a pleiotropic cytokine with potential applications in oncology.Interleukin 21 - its potential role in the therapy of B-cell lymphomas.β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases.Aberrant expression and biological significance of Sox2, an embryonic stem cell transcriptional factor, in ALK-positive anaplastic large cell lymphoma.Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling.Elevated follicular helper T cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves' disease.Interleukin-21 is associated with disease activity in patients with Graves' disease.

P2860

Q26801053-AC04646A-CF2A-412C-A4FA-EA89631C6F0D Q33924261-C29D0C4F-2A45-4C1E-B4B9-A394D2F7CBA0 Q34542109-4040A667-57F6-4822-8365-BB9C5966302F Q36018118-93429132-F4FC-466D-95B7-97F980720BB2 Q36285745-BFC38B83-136B-4D1E-B79C-843B3254ED09 Q36469217-7F3355FA-B04E-40FF-88AD-088B6B1CC568 Q37595688-664AFA8B-FFCB-419F-9223-DC4EF639E590 Q37695012-FCCBDC22-452B-4BD7-B345-863B03E37720 Q37716643-1DFA3109-45D2-4C2E-82E9-3EB6DBA7C560 Q37808703-223A208B-6E99-49CB-8207-E0FDAD831DE9 Q38003641-85B5080A-129B-44B4-904F-51EF080521CF Q38101044-B44DE843-831B-4A53-A67A-A2A17A1B3D23 Q38106810-C54FC97B-7C02-4329-836C-9496F4CB7AC2 Q38471387-B4178FA5-FF4E-407F-BB92-77B35EDC5CE2 Q38894228-B5474CCE-1042-44CF-AA65-C41F07EA4D03 Q39640523-D7FBA873-4D79-4CB0-B72B-1DE8B4298039 Q41108412-44646BDC-CCAA-4914-80E4-ED0731DAC039 Q42254184-6695602B-9858-4DCA-A619-292DB89F2C20 Q42322572-2BA43CCC-39AD-4C2F-BFAB-93D7A63AC91B Q50672422-7A1EACE0-912A-4B6B-9172-50257250F0AE Q53534683-7BCFFF0C-A129-4659-96A1-767F0D9C2AA5 Q54519728-E347BCFE-47BD-4138-AEBB-2331843EA7CA

P2860

IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.

http://www.wikidata.org/entity/Q37278507

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 16 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@en

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@nl

type

label

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@en

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@nl

prefLabel

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@en

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@nl

P1433

Q37278507-30DDCB29-988A-4A0B-844B-85F662FCF460

P1476

Q37278507-E13CD394-F2E6-43F5-86CC-1CEDC8B90818

P2093

Q37278507-067187DA-2076-4A71-9FEC-2D0B4E874FEE

Q37278507-25BEFC44-D73E-4F7B-BF53-86354682F85D

Q37278507-6E31952E-60BC-4D3E-9DC3-D8492C3D9DBD

Q37278507-9DB254BA-F13D-4D2A-B0F5-A1256D443001

Q37278507-9EAB5F91-BD5D-4059-9296-3B7BAF84F5A4

Q37278507-BE6B3BCA-0C84-433B-9381-7828FD574B17

Q37278507-CE0B7844-7C75-4182-99E3-4DD1AD6A9D92

P2860

Q37278507-0158F736-333C-4C3F-9520-4C7E10BF05B8

Q37278507-06A603A3-0210-4089-8742-6F80AA8CBFF7

Q37278507-0788FC0A-47CB-4C75-A8EF-326022EE4849

Q37278507-0C8C4204-224D-4E59-BF7D-CCB175E02779

Q37278507-0D85B955-B981-4CA9-819B-D1B9A800B291

Q37278507-0DB89ECC-9EC9-4F0F-8BD3-170DE704D422

Q37278507-1B3F77E1-38F8-457E-8AD8-4798503BE01D

Q37278507-24F45D23-A164-4FFD-9270-3783FF4C5A46

Q37278507-2666B7BC-70F8-4B5F-BC31-763B01213773

Q37278507-2BB80C80-B03C-4528-B1A6-1A6E4E227C6D

P304

Q37278507-41E2970D-492D-4B29-8EBA-897CED6335ED

P31

Q37278507-65C84A70-2606-4FD6-8DCC-0E1526A0A32B

P356

Q37278507-5BE53058-73C3-4DAE-9B6F-70D80A98A3CA

P407

Q37278507-60FC3947-47BC-4F01-82EA-B33430752825

P433

Q37278507-3BB5DAB3-0BC6-4344-B036-4EEEDCA6B8FA

P478

Q37278507-F7BCD077-92B7-4C42-A682-33C574F7DDFA

P577

Q37278507-6D89E7C7-F6F6-403D-A92B-536EBA79B300

P5875

Q37278507-6C373E7A-870C-45EA-B777-47F186B55DE2

P698

Q37278507-3B7E5139-6E5D-44BD-8CA8-B930D4D19AD8

P932

Q37278507-C2C57755-A3A7-4165-BE11-E6BB820E3C36

P356

AJPATH.2009.080982

P1433

The American Journal of Pathology

P1476

IL-21 contributes to JAK3/STAT ...... naplastic large cell lymphoma.

@en

P2093

Hesham M Amin

http://www.w3.org/2001/XMLSchema#string

Jennifer Dien Bard

http://www.w3.org/2001/XMLSchema#string

Mona Anand

http://www.w3.org/2001/XMLSchema#string

Pascal Gelebart

http://www.w3.org/2001/XMLSchema#string

Raymond Lai

http://www.w3.org/2001/XMLSchema#string

Samar A Hegazy

http://www.w3.org/2001/XMLSchema#string

Zoulika Zak

http://www.w3.org/2001/XMLSchema#string

P2860

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

P304

825-834

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.2353/AJPATH.2009.080982

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

175

http://www.w3.org/2001/XMLSchema#string

P577

2009-07-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26676684

http://www.w3.org/2001/XMLSchema#string

P698

19608866

http://www.w3.org/2001/XMLSchema#string

P932

2716977

http://www.w3.org/2001/XMLSchema#string