Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.
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Neuroendorine and Epigentic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic SyndromeHypothalamic miRNAs: emerging roles in energy balance controlSubstantial and robust changes in microRNA transcriptome support postnatal development of the hypothalamus in rat.Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells.A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3'UTR.Characterization of the hypothalamic transcriptome in response to food deprivation reveals global changes in long noncoding RNA, and cell cycle response genes.MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein kinase 8.Hypothalamic regulation of energy balance: a key role for DICER miRNA processing in arcuate POMC neurons.The epigenetic regulation of the opioid system: new individualized prompt prevention and treatment strategies.Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease?Molecular regulation of hypothalamic development and physiological functions.Neuropeptide Y in Alcohol Addiction and Affective Disorders.Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism.The Role of MicroRNA in the Modulation of the Melanocortinergic System.Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the Magel2-null mouse model of Prader-Willi syndrome.Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function.
P2860
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P2860
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Deletion of miRNA processing e ...... on and development of obesity.
@en
Deletion of miRNA processing e ...... on and development of obesity.
@nl
type
label
Deletion of miRNA processing e ...... on and development of obesity.
@en
Deletion of miRNA processing e ...... on and development of obesity.
@nl
prefLabel
Deletion of miRNA processing e ...... on and development of obesity.
@en
Deletion of miRNA processing e ...... on and development of obesity.
@nl
P2093
P2860
P50
P1433
P1476
Deletion of miRNA processing e ...... ion and development of obesity
@en
P2093
Marc Schneeberger
Montserrat García-Lavandeira
Ramon Gomis
Yaiza Esteban
P2860
P356
10.1016/J.MOLMET.2012.10.001
P577
2012-11-12T00:00:00Z