A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
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Mitochondrial targets for pharmacological intervention in human diseasePrediction of Genetic Interactions Using Machine Learning and Network PropertiesPredicting human genetic interactions from cancer genome evolutionTheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.A frameshift mutation in MOCOS is associated with familial renal syndrome (xanthinuria) in Tyrolean Grey cattle.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens.Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells.Predicting chemotherapeutic drug combinations through gene network profilingTowards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells.Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment.CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming.The cancer cell map initiative: defining the hallmark networks of cancer.Synthetic lethality and cancer.Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines.Cytokinetic effects of Wee1 disruption in pancreatic cancer.Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.Measuring error rates in genomic perturbation screens: gold standards for human functional genomicsSystematic epistatic mapping of cellular processes."Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma.A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.Link synthetic lethality to drug sensitivity of cancer cells.The exomic landscape of t(14;18)-negative diffuse follicular lymphoma with 1p36 deletion.Dual gene activation and knockout screen reveals directional dependencies in genetic networks.EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.Harnessing synthetic lethality to predict the response to cancer treatment.
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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A negative genetic interaction ...... ls cancer cell vulnerabilities
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A negative genetic interaction ...... s cancer cell vulnerabilities.
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type
label
A negative genetic interaction ...... ls cancer cell vulnerabilities
@en
A negative genetic interaction ...... s cancer cell vulnerabilities.
@nl
prefLabel
A negative genetic interaction ...... ls cancer cell vulnerabilities
@en
A negative genetic interaction ...... s cancer cell vulnerabilities.
@nl
P2093
P2860
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P356
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A negative genetic interaction ...... ls cancer cell vulnerabilities
@en
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Alla Buzina
Anastasia Baryshnikova
Andrew Emili
Anthony B Mak
Azin Sayad
Brenda Andrews
Charles Boone
Dahlia Kasimer
Franco J Vizeacoumar
Frederick S Vizeacoumar
P2860
P356
10.1038/MSB.2013.54
P577
2013-10-08T00:00:00Z