Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. - Wikidata - wikimedia - TriplyDB

Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy.

Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy.

http://www.wikidata.org/entity/Q37292752

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Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic cardiomyopathy Xin proteins and intercalated disc maturation, signaling and diseases Mutations with pathogenic potential in proteins located in or at the composite junctions of the intercalated disk connecting mammalian cardiomyocytes: a reference thesaurus for arrhythmogenic cardiomyopathies and for Naxos and Carvajal diseases Structural determinants of cadherin-23 function in hearing and deafness Pathogenesis of Arrhythmogenic Cardiomyopathy Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy Histological and ultrastructural abnormalities in murine desmoglein 2-mutant hearts Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes Mechanistic basis of desmosome-targeted diseases Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?Protein LUMA is a cytoplasmic plaque constituent of various epithelial adherens junctions and composite junctions of myocardial intercalated disks: a unifying finding for cell biology and cardiology.In vitro functional analyses of arrhythmogenic right ventricular cardiomyopathy-associated desmoglein-2-missense variations Cell junctions in the specialized conduction system of the heart Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.Mechanotransduction in cardiac hypertrophy and failure.Clinical phenotype and diagnosis of arrhythmogenic right ventricular cardiomyopathy in pediatric patients carrying desmosomal gene mutations.Genetics of inherited cardiomyopathy.Diagnostic dilemmas: overlapping features of brugada syndrome and arrhythmogenic right ventricular cardiomyopathy Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report.Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/β-catenin signaling.A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model.Pathophysiology of arrhythmogenic cardiomyopathy.Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C): a review of molecular and clinical literature.The changing spectrum of arrhythmogenic (right ventricular) cardiomyopathy.Mouse models in arrhythmogenic right ventricular cardiomyopathy.Right ventricle in pulmonary hypertension.When rare illuminates common: how cardiocutaneous syndromes transformed our perspective on arrhythmogenic cardiomyopathy.Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy Science and practice of arrhythmogenic cardiomyopathy: A paradigm shift.Desmosomes in the heart: a review of clinical and mechanistic analyses.Alterations in cell adhesion proteins and cardiomyopathy.Arrhythmogenic cardiomyopathy: a disease of intercalated discs.The research venture in arrhythmogenic right ventricular cardiomyopathy: a paradigm of translational medicine.Whole Genome Sequence Identified a Rare Homozygous Pathogenic Mutation of the DSG2 Gene in a Familial Arrhythmogenic Cardiomyopathy Involving Both Ventricles.

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Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy.

http://www.wikidata.org/entity/Q37292752

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 July 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Myocyte necrosis underlies pro ...... ht ventricular cardiomyopathy.

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Andrea Nava

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Antoon F M Moorman

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Barbara Bauce

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Brendon P Scicluna

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Carol Ann Remme

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Connie R Bezzina

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Cristina Basso

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Gaetano Thiene

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Hanno L Tan

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Jacques M T de Bakker

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P2860

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.

A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy

Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy

Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy

Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion

Structural basis of calcium-induced E-cadherin rigidification and dimerization

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma

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1787-1802

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scholarly article

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10.1084/JEM.20090641

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8

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206

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Arthur A M Wilde

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2009-07-27T00:00:00Z

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26698885

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19635863

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arrhythmogenic right ventricular cardiomyopathy

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2722163

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